"Antibiotic resistance of Helicobacter pylori isolated from children in Chongqing, China"

作者全名："Geng, Tian; Yu, Zhong-Su; Zhou, Xi-Xi; Liu, Bo; Zhang, Hui-Hua; Li, Zhong-Yue"

作者地址："[Geng, Tian; Yu, Zhong-Su; Zhou, Xi-Xi; Liu, Bo; Zhang, Hui-Hua; Li, Zhong-Yue] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Gastroenterol, 136,2nd Zhongshan Rd, Chongqing, Peoples R China; [Geng, Tian; Yu, Zhong-Su; Zhou, Xi-Xi; Liu, Bo; Zhang, Hui-Hua; Li, Zhong-Yue] Chongqing Med Univ, Childrens Hosp, Minist Educ, Key Lab Child Dev & Disorders, 136,2nd Zhongshan Rd, Chongqing, Peoples R China; [Geng, Tian; Yu, Zhong-Su; Zhou, Xi-Xi; Liu, Bo; Zhang, Hui-Hua; Li, Zhong-Yue] Chongqing Med Univ, Childrens Hosp, China Int Sci & Technol Cooperat Base Child Dev &, 136,2nd Zhongshan Rd, Chongqing, Peoples R China; [Geng, Tian; Yu, Zhong-Su; Zhou, Xi-Xi; Liu, Bo; Zhang, Hui-Hua; Li, Zhong-Yue] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Pediat, 136,2nd Zhongshan Rd, Chongqing, Peoples R China"

通信作者："Li, ZY (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Gastroenterol, 136,2nd Zhongshan Rd, Chongqing, Peoples R China.; Li, ZY (通讯作者)，Chongqing Med Univ, Childrens Hosp, Minist Educ, Key Lab Child Dev & Disorders, 136,2nd Zhongshan Rd, Chongqing, Peoples R China.; Li, ZY (通讯作者)，Chongqing Med Univ, Childrens Hosp, China Int Sci & Technol Cooperat Base Child Dev &, 136,2nd Zhongshan Rd, Chongqing, Peoples R China.; Li, ZY (通讯作者)，Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Pediat, 136,2nd Zhongshan Rd, Chongqing, Peoples R China."

来源：EUROPEAN JOURNAL OF PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000787147800001

JCR分区：Q1

影响因子：3.6

年份：2022

卷号：181

期号：7

开始页：2715

结束页：2722

文献类型：Article

关键词：Helicobacter pylori (H. pylori); Antibiotic resistance; Children

摘要："The resistance of Helicobacter pylori (H. pylori) to antibiotics has been increasing worldwide and varies across different geographic areas and times. Limited studies reported the prevalence of antibiotic resistance and its related gene mutations in children in Chongqing, a city located in southwest China. We collected 112 H. pylori strains isolated from gastric biopsies of 156 children at Children's Hospital of Chongqing Medical University and calculated resistance rates of these strains to six antibiotics. The A2143G and A2142G mutations in 23S rRNA gene, which are related to clarithromycin resistance, and Asn87 and Asp91 mutations in gyrA gene, which are related to levofloxacin resistance, were investigated in 102 strains. The resistance rates to clarithromycin, metronidazole, and levofloxacin were 47.3% (53/112), 88.4% (99/112), and 18.8% (21/112), respectively. No resistance to amoxicillin, tetracycline, and furazolidone was observed. Dual and triple resistance percentages were 37.5% (42/112) and 10.7% (12/112), respectively. The detection rate of A2143G mutation in 23S rRNA gene was 83.3% (40/48). The detection rates of mutations of Asn87 and Asp91 in gyrA gene were 52.6% (10/19) and 36.8% (7/19), respectively. Conclusion: The prevalence of H. pylori resistance to clarithromycin, metronidazole, and levofloxacin was high in children in Chongqing, China. The A2143G mutation was detected in most clarithromycin-resistant strains, and Asn87 and Asp91 of gyrA mutation points were common in levofloxacin-resistant strains. In clinical practice, anti-H. pylori therapy should be individualized based on a susceptibility test."

基金机构：Science and Health Joint Medical Research Program of Chongqing [2019ZDXM045]

基金资助正文：This study was supported by the Science and Health Joint Medical Research Program of Chongqing (2019ZDXM045).