Surface engineered iron oxide nanozyme for synergistic chemodynamic/ photodynamic therapy with glutathione depletion and hypoxia relief

作者全名："Zhu, Xianglong; Ni, Kaiyuan; Zhao, Zhenghuan; Li, Muyao; Huo, Linlin; Zeng, Jie; Zhu, Guifen; Shi, Saige; Liu, Xiangqing; Huang, Guoming; Jia, Jianhua; Qiu, Dachuan"

作者地址："[Zhao, Zhenghuan; Li, Muyao; Huo, Linlin; Zeng, Jie; Zhu, Guifen; Jia, Jianhua; Qiu, Dachuan] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China; [Zhu, Guifen; Liu, Xiangqing] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China; [Zhu, Xianglong; Shi, Saige] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China; [Ni, Kaiyuan] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA"

通信作者："Zhao, ZH (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China.; Zhu, XL (通讯作者)，Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China.; Ni, KY (通讯作者)，MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02142 USA."

来源：CHEMICAL ENGINEERING JOURNAL

ESI学科分类：ENGINEERING

WOS号：WOS:000795157300001

JCR分区：Q1

影响因子：15.1

年份：2022

卷号：440

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Synergistic therapy; GSH depletion; Hypoxia relief; Tumor microenvironment

摘要："Reactive oxygen species (ROS)-based therapies, such as photodynamic therapy (PDT) and chemodynamic therapy (CDT), hold great promise to cancer treatment. However, their efficacies are subject to hypoxia and overexpressed glutathione (GSH) in tumor microenvironment (TME). Herein, we develop Mn (II) ions and pyropheophorbide (PPa) engineered iron oxide nanoparticles (IMOP) to regulate tumor hypoxia and deplete GSH for synergistic CDT/PDT. In the TME, IMOP could catalytically decompose hydrogen peroxide (H2O2) to hydroxyl radicals (.OH) as a CDT agent. Significantly, IMOP exhibits high catalase-like and glutathione peroxidaselike activities simultaneously. Once enriching into tumor, IMOP could catalyze H2O2 to oxygen (O2) to overcome hypoxic TME for improved 1O2 generation via PPa-mediated PDT. Meanwhile, the glutathione peroxidase-like activity ensure IMO to reduce the intratumoral GSH concentration and further reduce the consumption of active ROS during therapy. We demonstrated that the regulation by IMOP elicited synergistic CDT/PDT efficacy for enhanced ROS-based cancer treatment both in vitro and in vivo. Moreover, the existence of Mn (II) allowed IMO with T1 contrast behavior to monitor the progress of CDT/PDT in magnetic resonance imaging. This work provides a new guidance for designing TME-based anticancer platform for effective and precise cancer treatment."

基金机构："National Natural Science Foundation of China [81601607, 81971609]; Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent) [CQYC201905077]; Creative Research Group of CQ University [CXQT21017]"

基金资助正文："Acknowledgements This work was supported by the National Natural Science Foundation of China (81601607 and 81971609) , Chongqing High-level Personnel of Special Support Program (Youth Top-notch Talent CQYC201905077) , and Creative Research Group of CQ University (CXQT21017) ."