Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles

作者全名："Zou, Hongmi; Li, Meng; Li, Xing; Zheng, Wendi; Kuang, Hongyu; Wang, Menglei; Zhang, Wenli; Ran, Haitao; Ma, Huafeng; Zhou, Xiyuan"

作者地址："[Zou, Hongmi; Li, Meng; Li, Xing; Zheng, Wendi; Wang, Menglei; Ma, Huafeng; Zhou, Xiyuan] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 2, Chongqing, Peoples R China; [Kuang, Hongyu] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhang, Wenli] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Ran, Haitao] Chongqing Med Univ, Dept Ultrasound, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Ma, HF; Zhou, XY (通讯作者)，74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：DRUG DELIVERY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000804448800001

JCR分区：Q1

影响因子：6

年份：2022

卷号：29

期号：1

开始页：1785

结束页：1799

文献类型：Article

关键词：Nanoparticles; combination therapy; dual-mode imaging; target; retinoblastoma

摘要："Retinoblastoma (Rb) represents 3% of all childhood malignancies and seriously endangers children's lives and quality of life. Early diagnosis and treatment can save children's vision as much as possible. Multifunctional nanoparticles have become a research hotspot in recent years and are expected to realize the integration of early diagnosis and early treatment. Therefore, we report a nanoparticle with dual-mode imaging, photothermal therapy, and immune activation: carbonized MOF nanoparticles (CM NPs) loaded with the immune polypeptide tuftsin (CMT NPs). The dual-mode imaging ability, antitumor effect, and macrophage immunity activation ability of these nanoparticles combined with laser irradiation were studied. The biosafety of CMT NPs was detected. The multifunctional magnetic nanoparticles enhanced photoacoustic (PA) and magnetic resonance (MR) imaging in vivo and in vitro, facilitating diagnosis and efficacy evaluation. The combined effect of CMT NPs and laser irradiation was recorded and verified. Through the accumulation of magnetic field nanoparticles in tumors, the photothermal conversion of nanoparticles under laser irradiation led directly to tumor apoptosis/necrosis, and the release of tuftsin induced macrophage M1-type activation, resulting in antitumor immune effects. Enhanced PA/MR imaging CMT NPs have great potential in dual-mode image-guided laser/immune cotherapy. The nanoparticles have high biosafety and have potential in cancer treatment."

基金机构："National Natural Science Foundation of China [82070976]; National Natural Science Foundation for Youth of China [81901765, 81501487, 81601508]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 82070976) and National Natural Science Foundation for Youth of China (Nos. 81901765, 81501487, 81601508)."