The role of MicroRNA networks in tissue-specific direct and indirect effects of metformin and its application

作者全名："Yang, Qinzhi; Wang, Gang; Fang, Dan; Gao, Xiaojun; Liang, Yu; Wang, Liqun; Wu, Jianbo; Zeng, Min; Luo, Mao"

作者地址："[Yang, Qinzhi; Fang, Dan; Gao, Xiaojun; Wang, Liqun; Wu, Jianbo; Luo, Mao] Southwest Med Univ, Drug Discovery Res Ctr, Key Lab Med Electrophysiol, Minist Educ, Luzhou, Peoples R China; [Yang, Qinzhi; Fang, Dan; Gao, Xiaojun; Wang, Liqun; Wu, Jianbo; Luo, Mao] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Cardiovasc Pharmacol, Luzhou, Sichuan, Peoples R China; [Wang, Gang] Chongqing Med Univ, Sch Pharm, Chongqing, Peoples R China; [Liang, Yu; Luo, Mao] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Integrated Tradit Chinese & Western Med, Luzhou, Sichuan, Peoples R China; [Zeng, Min; Luo, Mao] Southwest Med Univ, Dept Pharm, Affiliated Hosp, Luzhou, Sichuan, Peoples R China"

通信作者："Zeng, M; Luo, M (通讯作者)，Southwest Med Univ, Dept Pharm, Affiliated Hosp, Luzhou, Sichuan, Peoples R China."

来源：BIOMEDICINE & PHARMACOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000804954200008

JCR分区：Q1

影响因子：7.5

年份：2022

卷号：151

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Metformin; MicroRNAs; Tissue-specific direct and indirect effects; Therapeutic application

摘要："Metformin is a first-line oral antidiabetic agent that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The specific regulatory details and mechanisms underlying these benefits are still unclear and require further investigation. There is recent mounting evidence that metformin has pleiotropic effects on the target tissue development in metabolic organs, including adipose tissue, the gastrointestinal tract and the liver. The mechanism of actions of metformin are divided into direct effects on target tissues and indirect effects via non-targeted tissues. MicroRNAs (miRNAs) are a class of endogenous, noncoding, negative gene regulators that have emerged as important regulators of a number of diseases, including type 2 diabetes mellitus (T2DM). Metformin is involved in many aspects of miRNA regulation, and metformin treatment in T2DM should be associated with other miRNA targets. A large number of miRNAs regulation by metformin in target tissues"

基金机构：National Natural Science Foundation of China [81800434]; Sichuan Province Science and Technology Agency [2019YJ0487]; Foundation of Luzhou Municipal Science and Technology Bureau [2021-RCM-113]

基金资助正文："This work was supported by the National Natural Science Foundation of China [grant numbers 81800434] , Grant of Sichuan Province Science and Technology Agency Grant [2019YJ0487] , Foundation of Luzhou Municipal Science and Technology Bureau [2021-RCM-113] ."