The role of oral microbiome in periodontitis under diabetes mellitus

作者全名："Qin, Han; Li, Guangyue; Xu, Xiaohui; Zhang, Chuangwei; Zhong, Wenjie; Xu, Shihan; Yin, Yuanyuan; Song, Jinlin"

作者地址："[Qin, Han; Li, Guangyue; Xu, Xiaohui; Zhang, Chuangwei; Zhong, Wenjie; Xu, Shihan; Yin, Yuanyuan; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China; [Qin, Han; Li, Guangyue; Xu, Xiaohui; Zhang, Chuangwei; Zhong, Wenjie; Xu, Shihan; Yin, Yuanyuan; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Qin, Han; Li, Guangyue; Xu, Xiaohui; Zhang, Chuangwei; Zhong, Wenjie; Xu, Shihan; Yin, Yuanyuan; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing, Peoples R China"

通信作者："Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, 426 Songshibei Rd, Chongqing 401147, Peoples R China."

来源：JOURNAL OF ORAL MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000805647200001

JCR分区：Q2

影响因子：4.5

年份：2022

卷号：14

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Diabetes mellitus; periodontitis; periodontal disease; subgingival microbiome; oral microbiome; next-generation sequencing

摘要："Periodontitis is among most common human inflammatory diseases and characterized by destruction of tooth-supporting tissues that will eventually lead to tooth loss. Diabetes mellitus (DM) is a group of metabolic disorders characterized by chronic hyperglycemia which results from defects in insulin secretion and/or insulin resistance. Numerous studies have provided evidence for the inter-relationship between DM and periodontitis that has been considered as the sixth most frequent complication of DM. However, the mechanisms are not fully understood yet. The impact of DM on periodontitis through hyperglycemia and inflammatory pathways is well described, but the effects of DM on oral microbiota remain controversial according to previous studies. Recent studies using next-generation sequencing technology indicate that DM can alter the biodiversity and composition of oral microbiome especially subgingival microbiome. This may be another mechanism by which DM risks or aggravates periodontitis. Thus, to understand the role of oral microbiome in periodontitis of diabetics and the mechanism of shifts of oral microbiome under DM would be valuable for making specific therapeutic regimens for treating periodontitis patients with DM or preventing diabetic patients from periodontitis. This article reviews the role of oral microbiome in periodontal health (symbiosis) and disease (dysbiosis), highlights the oral microbial shifts under DM and summarizes the mechanism of the shifts."

基金机构："National Natural Science Foundation of China [81800938, 31971282, 82001063]; Post-doctoral Program of Natural Science Foundation of Chongqing [cstc2020jcyj-bshX0108]; Program for Team Building of Research Supervisor in Chongqing [dstd201903]; Program for Innovation Team Building at Institutions of Higher Education in Chongqing [CXTDG201602006]"

基金资助正文："This work was supported by the National Natural Science Foundation of China [81800938], National Natural Science Foundation of China [31971282], National Natural Science Foundation of China [82001063], Post-doctoral Program of Natural Science Foundation of Chongqing [cstc2020jcyj-bshX0108], Program for Team Building of Research Supervisor in Chongqing [dstd201903] and Program for Innovation Team Building at Institutions of Higher Education in Chongqing [CXTDG201602006]."