Interactions between central nervous system and peripheral metabolic organs

作者全名："Zeng, Wenwen; Yang, Fan; Shen, Wei L.; Zhan, Cheng; Zheng, Peng; Hu, Ji"

作者地址："[Zeng, Wenwen] Tsinghua Univ, Sch Med, Inst Immunol, Beijing 100084, Peoples R China; [Zeng, Wenwen] Tsinghua Univ, Sch Med, Dept Basic Med Sci, Beijing 100084, Peoples R China; [Zeng, Wenwen] Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China; [Zeng, Wenwen] Beijing Key Lab Immunol Res Chron Dis, Beijing 100084, Peoples R China; [Yang, Fan] Chinese Acad Sci, Shenzhen Hong Kong Inst Brain Sci, Brain Cognit & Brain Dis Inst, Shenzhen Inst Adv Technol,Shenzhen Fundamental Re, Shenzhen 518055, Peoples R China; [Shen, Wei L.; Hu, Ji] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China; [Zhan, Cheng] Univ Sci & Technol China, Affiliated Hosp USTC 1, Sch Life Sci, Dept Hematol,Hefei Natl Lab Phys Sci Microscale,D, Hefei 230026, Peoples R China; [Zhan, Cheng] Natl Inst Biol Sci, Beijing 102206, Peoples R China; [Zhan, Cheng] Tsinghua Univ, Tsinghua Inst Multidisciplinary Biomed Res, Beijing 100084, Peoples R China; [Zheng, Peng] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400042, Peoples R China; [Zheng, Peng] Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China; [Zheng, Peng] Chongqing Med Univ, Collaborat Innovat Ctr Brain Sci, Chongqing 400016, Peoples R China; [Zheng, Peng] Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China"

通信作者："Zeng, WW (通讯作者)，Tsinghua Univ, Sch Med, Inst Immunol, Beijing 100084, Peoples R China.; Zeng, WW (通讯作者)，Tsinghua Univ, Sch Med, Dept Basic Med Sci, Beijing 100084, Peoples R China.; Zeng, WW (通讯作者)，Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China.; Zeng, WW (通讯作者)，Beijing Key Lab Immunol Res Chron Dis, Beijing 100084, Peoples R China.; Yang, F (通讯作者)，Chinese Acad Sci, Shenzhen Hong Kong Inst Brain Sci, Brain Cognit & Brain Dis Inst, Shenzhen Inst Adv Technol,Shenzhen Fundamental Re, Shenzhen 518055, Peoples R China.; Shen, WL (通讯作者)，ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China.; Zhan, C (通讯作者)，Univ Sci & Technol China, Affiliated Hosp USTC 1, Sch Life Sci, Dept Hematol,Hefei Natl Lab Phys Sci Microscale,D, Hefei 230026, Peoples R China.; Zhan, C (通讯作者)，Natl Inst Biol Sci, Beijing 102206, Peoples R China.; Zhan, C (通讯作者)，Tsinghua Univ, Tsinghua Inst Multidisciplinary Biomed Res, Beijing 100084, Peoples R China.; Zheng, P (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing 400042, Peoples R China.; Zheng, P (通讯作者)，Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China.; Zheng, P (通讯作者)，Chongqing Med Univ, Collaborat Innovat Ctr Brain Sci, Chongqing 400016, Peoples R China.; Zheng, P (通讯作者)，Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China."

来源：SCIENCE CHINA-LIFE SCIENCES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000819349300001

JCR分区：Q1

影响因子：9.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：central nervous system; peripheral organs; adipose tissues; bone metabolism; gut microbiota

摘要："According to Descartes, minds and bodies are distinct kinds of ""substance"", and they cannot have causal interactions. However, in neuroscience, the two-way interaction between the brain and peripheral organs is an emerging field of research. Several lines of evidence highlight the importance of such interactions. For example, the peripheral metabolic systems are overwhelmingly regulated by the mind (brain), and anxiety and depression greatly affect the functioning of these systems. Also, psychological stress can cause a variety of physical symptoms, such as bone loss. Moreover, the gut microbiota appears to play a key role in neuropsychiatric and neurodegenerative diseases. Mechanistically, as the command center of the body, the brain can regulate our internal organs and glands through the autonomic nervous system and neuroendocrine system, although it is generally considered to be outside the realm of voluntary control. The autonomic nervous system itself can be further subdivided into the sympathetic and parasympathetic systems. The sympathetic division functions a bit like the accelerator pedal on a car, and the parasympathetic division functions as the brake. The high center of the autonomic nervous system and the neuroendocrine system is the hypothalamus, which contains several subnuclei that control several basic physiological functions, such as the digestion of food and regulation of body temperature. Also, numerous peripheral signals contribute to the regulation of brain functions. Gastrointestinal (GI) hormones, insulin, and leptin are transported into the brain, where they regulate innate behaviors such as feeding, and they are also involved in emotional and cognitive functions. The brain can recognize peripheral inflammatory cytokines and induce a transient syndrome called sick behavior (SB), characterized by fatigue, reduced physical and social activity, and cognitive impairment. In summary, knowledge of the biological basis of the interactions between the central nervous system and peripheral organs will promote the full understanding of how our body works and the rational treatment of disorders. Thus, we summarize current development in our understanding of five types of central-peripheral interactions, including neural control of adipose tissues, energy expenditure, bone metabolism, feeding involving the brain-gut axis and gut microbiota. These interactions are essential for maintaining vital bodily functions, which result in homeostasis, i.e., a natural balance in the body's systems."

基金机构："National Natural Science Foundation of China [31822026, 31822018, 31770936, 82072489, 32122039]; National Key R&D Program of China [2017YFA0205903, 2017YFA0505800, 2021ZD020390]; Key Research Program of Frontier Sciences of Chinese Academy of Sciences [QYZDB-SSW-SMC056]; Beijing Natural Science Foundation [5222010]; Tsinghua University (School of Medicine)-Xiamen Changgeng Hospital Co. Ltd. Joint Research Center for Anaphylactic Disease"

基金资助正文："This work was supported by the National Natural Science Foundation of China (31822026, 31822018, 31770936, 82072489, 32122039), the National Key R&D Program of China (2017YFA0205903, 2017YFA0505800, 2021ZD020390), the Key Research Program of Frontier Sciences of Chinese Academy of Sciences (QYZDB-SSW-SMC056), Beijing Natural Science Foundation (5222010), and the Tsinghua University (School of Medicine)-Xiamen Changgeng Hospital Co. Ltd. Joint Research Center for Anaphylactic Disease."