PgC(3)Mg metal-organic cages functionalized hydrogels with enhanced bioactive and ROS scavenging capabilities for accelerated bone regeneration

作者全名："Tan, Xiujun; Wu, Jiayi; Wang, Rui; Wang, Chenglin; Sun, Yimin; Wang, Zhenming; Ye, Ling"

作者地址："[Tan, Xiujun; Wu, Jiayi; Wang, Rui; Wang, Chenglin; Sun, Yimin; Wang, Zhenming; Ye, Ling] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China; [Tan, Xiujun; Wu, Jiayi; Wang, Rui; Wang, Chenglin; Sun, Yimin; Wang, Zhenming; Ye, Ling] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China; [Tan, Xiujun] Chongqing Med Univ, Stomatol Hosp, Chongqing 401147, Peoples R China; [Ye, Ling] Sichuan Univ, Med X Ctr Mat, Chengdu 610065, Peoples R China"

通信作者："Wang, ZM; Ye, L (通讯作者)，Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China.; Wang, ZM; Ye, L (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China.; Ye, L (通讯作者)，Sichuan Univ, Med X Ctr Mat, Chengdu 610065, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000819526000001

JCR分区：Q1

影响因子：7

年份：2022

卷号：10

期号：28

开始页：5375

结束页：5387

文献类型：Article

关键词：　

摘要："The repair of large bone defects is an urgent problem in the clinic. Note that the disruption of redox homeostasis around bone defect sites might hinder the new bone reconstruction. The rational design of hydrogels for bone regeneration still faces the challenges of insufficient antioxidant capability and weak osteogenesis performance. Here, motivated by the versatile therapeutic functions of metal-organic cages, magnesium-seamed C-propylpyrogallol[4]arene (PgC(3)Mg) functionalized biodegradable and porous gelatin methacrylate (GelMA) hydrogels are constructed. The novel metal-organic cages endow hydrogels with highly bioactive characteristics and strong reactive oxygen species (ROS)-scavenging ability owing to the simultaneous release of bioactive Mg2+ ions and antioxidant phenolic hydroxyl-rich moieties. The in vitro results reveal that the PgC(3)Mg modified biocompatible hydrogels show higher expression of osteo-related genes and significantly eliminate the intracellular ROS levels of bone marrow-derived mesenchymal stem cells (BMSCs) against oxidative damage. Meanwhile, the bioactive and ROS scavenging hydrogels can accelerate bone regeneration in large cranial defects. Overall, this study may provide new insights into the designing of regenerative bone grafts with simultaneously enhanced osteogenic and antioxidant capabilities."

基金机构："National Science Fund for Distinguished Young Scholars of China [81825005]; National Natural Science Foundation of China [81702162]; Sichuan International Science, Technology Innovation Cooperation Project of Hong Kong, Macao and Taiwan [2021YFH0185]; West China School/Hospital of Stomatology, Sichuan University, China [QDJF2021-1]; Med-X Innovation Programme of Med-X Center for Materials, Sichuan University, China [MCM202001]"

基金资助正文："This work was supported by the National Science Fund for Distinguished Young Scholars of China (Grant No. 81825005), National Natural Science Foundation of China (Grant No. 81702162), Sichuan International Science, Technology Innovation Cooperation Project of Hong Kong, Macao and Taiwan (Grant No. 2021YFH0185), Research Funding from West China School/Hospital of Stomatology, Sichuan University, China (Grant No. QDJF2021-1) and Med-X Innovation Programme of Med-X Center for Materials, Sichuan University, China (MCM202001). The authors would like to thank Qiang Guo (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University) for help in using Micro CT. The authors also would like to thank Xi Wu (Analytical & Testing Center, Sichuan University) for help in using ICP-OES."