A Novel Fluorescent Probe Strategy Activated by beta-Glucuronidase for Assisting Surgical Resection of Liver Cancer

作者全名："Wang, Jiemin; Zhang, Liang; Su, Yaling; Qu, Yi; Cao, Yuping; Qin, Wenwu; Liu, Yun"

作者地址："[Wang, Jiemin; Su, Yaling; Qu, Yi; Cao, Yuping; Qin, Wenwu] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Wang, Jiemin; Su, Yaling; Qu, Yi; Cao, Yuping; Qin, Wenwu] Lanzhou Univ, Key Lab Special Funct Mat & Struct Design MOE, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China; [Su, Yaling; Qu, Yi; Cao, Yuping; Qin, Wenwu] Army Med Univ, Xinqiao Hosp, Dept Radiol, Chongqing 400037, Peoples R China; [Liu, Yun] Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing 400010, Peoples R China"

通信作者："Qin, WW (通讯作者)，Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.; Qin, WW (通讯作者)，Lanzhou Univ, Key Lab Special Funct Mat & Struct Design MOE, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China.; Qin, WW (通讯作者)，Army Med Univ, Xinqiao Hosp, Dept Radiol, Chongqing 400037, Peoples R China.; Liu, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Radiol, Chongqing 400010, Peoples R China."

来源：ANALYTICAL CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:000821278500001

JCR分区：Q1

影响因子：7.4

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：　

摘要："Liver cancer is a primary malignant tumor with a very high fatality rate, which has seriously threatened human health and life. In normal hepatocellular lesions, beta-glucuronidase (GLU) activity in liver cancer tissues is significantly increased. Therefore, GLU has become one of the important biomarkers of primary liver cancer. Here, a series of fluorescent probes (DCDH, DCDCH3, DCDOCH3, and DCDNO2) for early diagnosis of liver cancer and auxiliary surgical resection were successfully synthesized. Since the electron-withdrawing group -NO2 connected to the probe DCDNO2 accelerates the rapid cleavage of the glycosidic bond, DCDNO2 exhibits superior fluorescence properties that are more sensitive and rapid than the other three probes DCDH, DCDCH3, and DCDOCH3 when detecting GLU. DCDNO2 has been well-applied in real-time fluorescent visualization imaging for the detection of GLU activity in liver cancer cells and tumor tissues. In addition, DCDNO2 has also been successfully used in the early diagnosis of liver cancer and real-time imaging to guide the surgical resection of liver cancer tumors. Therefore, DCDNO2 has great potential for development in bioclinical medicine for the early detection and treatment of liver cancer."

基金机构："Natural Science Foundation of China [21771092, 81903561]; Fundamental Research Funds for the Central Universities [lzujbky-2021-kb17]; Special Fund Project of Guiding Scienti fi c, Technological Innovation Development of Gansu Province [2019ZX-04]; 111 Project [B20027]; State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China"

基金资助正文："The authors would like to thank the Natural Science Foundation of China (Nos. 21771092 and 81903561) . This work was supported by the Fundamental Research Funds for the Central Universities (No. lzujbky-2021-kb17) , the Special Fund Project of Guiding Scienti fi c, Technological Innovation Development of Gansu Province (No. 2019ZX-04) and the 111 Project, B20027. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China, funded this work."