"Comprehensive analysis of autophagy related long non-coding RNAs in prognosis, immunity, and treatment of muscular invasive bladder cancer"

作者全名："Tan, Wei; Yuan, Ye; Huang, Hao; Ma, Junhao; Li, Yadong; Gou, Yuanqing; Wu, Hao; Hu, Zili"

作者地址："[Tan, Wei; Yuan, Ye; Huang, Hao; Ma, Junhao; Li, Yadong; Gou, Yuanqing; Wu, Hao; Hu, Zili] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol Surg, Chongqing, Peoples R China"

通信作者："Wu, H; Hu, ZL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Urol Surg, Chongqing, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:000821555400004

JCR分区：Q2

影响因子：4.6

年份：2022

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："To predict disease outcome in muscle-invasive bladder cancer (MIBC), we constructed a prognostic autophagy-related (PAR) lncRNA signature. Comprehensive bioinformatics analyses were performed using data from TCGA and GTEx databases. Univariate Cox, and least absolute shrinkage and selection operator regression analyses were also performed, based on differentially expressed genes, to identify PAR-related lncRNAs to establish the signature. Furthermore, the Kaplan-Meier OS curve and receiver operating characteristic curve analyses were performed and a nomogram was constructed, all of which together confirmed the strong predictive ability of the constructed signature. Patients with MIBC were then divided into high- and low-risk groups. Gene enrichment and immune infiltration analyses revealed the potential mechanisms in MIBC. We also further evaluated the signature of molecules related to immune checkpoints and the sensitivity toward chemotherapeutic agents and antitumor-targeted drugs to find better treatment prescriptions. We identified a number of PAR-related lncRNA signatures, including HCP5, AC024060.1, NEAT1, AC105942.1, XIST, MAFG-DT, and NR2F1-AS1, which could be valuable prognostic tools to develop more efficient, individualized drug therapies for MIBC patients."

基金机构：Chongqing Science and Technology Benefiting project [cstc2016kjhmpt1001-5]

基金资助正文：This study was supported by the Chongqing Science and Technology Benefiting project [cstc2016kjhmpt1001-5].