Pulmonary artery enlargement predicts poor survival in patients with COPD: A meta-analysis

作者全名："Chen, Huaqiao; Shu, Tingting; Wang, Lu; Yang, Lingzhi; Hu, Changchun; Du, Shanshan; Wei, Huang"

作者地址："[Chen, Huaqiao; Shu, Tingting; Wang, Lu; Yang, Lingzhi; Du, Shanshan; Wei, Huang] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China; [Hu, Changchun] Chongqing Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Wei, H (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, Youyi Rd 1, Chongqing 400016, Peoples R China."

来源：PULMONARY CIRCULATION

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000821609700001

JCR分区：Q2

影响因子：2.6

年份：2022

卷号：12

期号：3

开始页：　

结束页：　

文献类型：Article

关键词：chronic obstructive pulmonary disease; computed tomography; odds ratio; prognosis; pulmonary vascular disease

摘要："No previous meta-analysis has evaluated the relationship between pulmonary artery enlargement (PAE) measured by computed tomography (CT) and prognosis for patients with chronic obstructive pulmonary disease (COPD). Recently, several studies have suggested poor survival and reduced exercise capacity in COPD patients with PAE on CT scan, but there were conflicting results. We aimed to assess the prognostic value of PAE-CT in patients with COPD. Relevant studies were identified by searching major databases. Pooled outcomes were determined to asst.% the prognostic value of PAE-CT in COPD patients. Eighteen studies including 5694 participants were included. PAE indicated higher mortality in COPD patients (odds ratio [OR] = 3.06; 95% confidence interval [95% CI]: 1.76-5.32; p < 0.0001), shorter 6-minute walk distance (mean difference [MD] = -67.53 m; 95% CI: -85.98 to -49.08; p <0.00001), higher pulmonary artery systolic pressure (MD = 15.65 mmHg; 95% CI: 13.20-18.11; p < 0.00001), longer length of hospital stay (MD = 2.92 days; 95% CI: 0.71-5.12; p = 0.009) and more severe symptom such as dyspnea (COPD Assessment Test MD = 3.14; 95% CI: 2.48-3.81; p <0.00001). We also conducted a subgroup analysis regarding the lung function and blood gas analysis for a stable period and acute exacerbation of COPD patients. In conclusion, PAE is significantly associated with mortality, lower exercise tolerance, and poor quality of life in patients with COPD. PAE may serve as a novel imaging biomarker for risk stratification in patients with COPD in the future."

基金机构：Chongqing municipal health and Health Committee [ZQNYXGDRCGZS2019001]

基金资助正文："The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Chongqing municipal health and Health Committee (grant number ZQNYXGDRCGZS2019001)."