Targeted intelligent mesoporous polydopamine nanosystems for multimodal synergistic tumor treatment

作者全名："Yang, Jiaxin; Zeng, Weinan; Fu, Xiaoxue; Chen, Lu; Yu, Xiaojuan; Xu, Ping; Huang, Wenyan; Leng, Feng; Yu, Chao; Yang, Zhangyou"

作者地址："[Yang, Jiaxin; Fu, Xiaoxue; Chen, Lu; Yu, Xiaojuan; Xu, Ping; Huang, Wenyan; Leng, Feng; Yu, Chao; Yang, Zhangyou] Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China; [Zeng, Weinan] Sichuan Univ, West China Hosp, Orthoped Res Inst, Dept Orthoped, Chengdu 610041, Peoples R China"

通信作者："Yu, C; Yang, ZY (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400016, Peoples R China."

来源：JOURNAL OF MATERIALS CHEMISTRY B

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000823748800001

JCR分区：Q1

影响因子：7

年份：2022

卷号：10

期号：29

开始页：5644

结束页：5654

文献类型：Article

关键词：　

摘要："Developing intelligent responsive platforms to carry out high-performance therapy is of great interest for the treatment of tumors and their metastases. However, effective drug loading, activity maintenance, off-target leakage, and response to collaborative therapy remain great challenges. Herein, a targeted intelligent responsive mesoporous polydopamine (MPDA) nanosystem was reported for use in gene-mediated photochemotherapy for synergistic tumor treatment. First, the MPDA was surface modified to maintain a positive charge near the surface and to impart active targeting. Then, gambogic acid (GA) was encapsulated in the MPDA, solidified by phase change materials (PCMs), and finally loaded with siRNA by electrostatic interactions to obtain the smart nanodelivery system (PPMD@GA/si). In vitro and in vivo experiments showed that it not only effectively avoids siRNA inactivation and accidental release of GA, but also possesses potential for targeted accumulation to tumor tissue and mild-temperature photothermal therapy and chemotherapy via near infrared (NIR) radiation. Additionally, the release of siRNA could also effectively inhibit tumor invasion and metastasis to realize multimodal synergistic therapy. Overall, our studies provide a promising idea for synergistic tumor and metastasis treatment based on vector construction."

基金机构："National Natural Science Foundation of China [81703156, 31800811]; Youth Talent Foundation in College of Pharmacy, Chongqing Medical University [YXY2019QNGD1]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0178]"

基金资助正文："This work was financially supported by the National Natural Science Foundation of China (No. 81703156 and 31800811), the Youth Talent Foundation in College of Pharmacy, Chongqing Medical University (No. YXY2019QNGD1) and the Natural Science Foundation of Chongqing (cstc2020jcyj-msxmX0178)."