Association between Selenium Status and Chronic Kidney Disease in Middle-Aged and Older Chinese Based on CHNS Data

作者全名："Xie, Changxiao; Zeng, Mao; Shi, Zumin; Li, Shengping; Jiang, Ke; Zhao, Yong"

作者地址："[Xie, Changxiao; Li, Shengping; Jiang, Ke; Zhao, Yong] Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China; [Xie, Changxiao; Li, Shengping; Jiang, Ke; Zhao, Yong] Chongqing Med Univ, Res Ctr Med & Social Dev, Chongqing 400016, Peoples R China; [Xie, Changxiao; Li, Shengping; Jiang, Ke; Zhao, Yong] Chongqing Med Univ, Res Ctr Publ Hlth Secur, Chongqing 400016, Peoples R China; [Zeng, Mao] Ctr Dis Control & Prevent Shuangliu Dist Chengdu, Chengdu 610000, Peoples R China; [Shi, Zumin] Qatar Univ, Dept Human Nutr, Coll Hlth Sci, QU Hlth, Doha 2713, Qatar; [Zhao, Yong] Chongqing Med Univ, Chongqing Key Lab Child Nutr & Hlth, Childrens Hosp, Chongqing 400014, Peoples R China"

通信作者："Zhao, Y (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Chongqing 400016, Peoples R China.; Zhao, Y (通讯作者)，Chongqing Med Univ, Res Ctr Med & Social Dev, Chongqing 400016, Peoples R China.; Zhao, Y (通讯作者)，Chongqing Med Univ, Res Ctr Publ Hlth Secur, Chongqing 400016, Peoples R China.; Zhao, Y (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Child Nutr & Hlth, Childrens Hosp, Chongqing 400014, Peoples R China."

来源：NUTRIENTS

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:000825522800001

JCR分区：Q1

影响因子：5.9

年份：2022

卷号：14

期号：13

开始页：　

结束页：　

文献类型：Article

关键词：selenium; chronic kidney disease (CKD); CHNS; ROC

摘要："Background: The association between selenium and chronic kidney disease (CKD) remains controversial. Population studies with large samples facilitate the reliability of conclusions. Objective: In this study, we aimed to describe the prevalence of a CKD association with selenium intake in middle-aged and older Chinese. Methods: Data for this study were obtained from the China Health and Nutrition Survey (CHNS). A total of 5381 participants (aged >= 45) with biochemical test data were included in the study. Logistic regression models were used to examine the association between diet selenium intake (quartile) and the prevalence of CKD. Results: A total of 942 (17.01%) participants had CKD. The prevalence of CKD was 23.33%, 20.32%, 14.98%, and 9.25% among participants with average selenium intakes of 21.5 +/- 4.82, 33.1 +/- 2.79, 43.8 +/- 3.70, and 67.0 +/- 13.97 mu g/day, respectively. In the fully adjusted model (Model 3), across the quartiles of selenium intake, the ORs for the prevalence of CKD were 1.00, 1.09 (95% CI 0.69-1.73), 0.82 (95% CI 0.49-1.38), and 0.43 (95% CI 0.22-0.85). The protein intake had a certain diagnostic significance for the selenium intake. Conclusions: An adequate selenium intake may have a positive effect on CKD. The influence of individual weight and location on the effect of selenium on CKD needs to be further explored."

基金机构：Chongqing Nutrition Society's project [2019001]

基金资助正文：Data in this research were from China Health and Nutrition Survey (CHNS). We also express our gratitude to Chongqing Nutrition Society's project (2019001): Research on dietary selenium intake and its relationship with hypertension and diabetes in middle-aged and older adults in Jiangjin Chongqing.