Alterations in White Matter Fiber Tracts Characterized by Automated Fiber-Tract Quantification and Their Correlations With Cognitive Impairment in Neuromyelitis Optica Spectrum Disorder Patients

作者全名："Yan, Zichun; Wang, Xiaohua; Zhu, Qiyuan; Shi, Zhuowei; Chen, Xiaoya; Han, Yongliang; Zheng, Qiao; Wei, Yiqiu; Wang, Jingjie; Li, Yongmei"

作者地址："[Yan, Zichun; Wang, Xiaohua; Zhu, Qiyuan; Shi, Zhuowei; Chen, Xiaoya; Han, Yongliang; Zheng, Qiao; Wei, Yiqiu; Wang, Jingjie; Li, Yongmei] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Wang, JJ; Li, YM (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000828025900001

JCR分区：Q2

影响因子：4.3

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：neuromyelitis optica spectrum disorder; white matter; diffusion tensor imaging; automated fiber-tract quantification; cognitive impairment

摘要："ObjectivesTo investigate whether patients with neuromyelitis optica spectrum disorder (NMOSD) have tract-specific alterations in the white matter (WM) and the correlations between the alterations and cognitive impairment. Materials and MethodsIn total, 40 patients with NMOSD and 20 healthy controls (HCs) who underwent diffusion tensor imaging (DTI) scan and neuropsychological scale assessments were enrolled. Automated fiber-tract quantification (AFQ) was applied to identify and quantify 100 equally spaced nodes of 18 specific WM fiber tracts for each participant. Then the group comparisons in DTI metrics and correlations between different DTI metrics and neuropsychological scales were performed. ResultsRegardless of the entire or pointwise level in WM fiber tracts, patients with NMOSD exhibited a decreased fractional anisotropy (FA) in the left inferior fronto-occipital fasciculus (L_IFOF) and widespread increased mean diffusion (MD), axial diffusivity (AD), and radial diffusivity (RD), especially for the thalamic radiation (TR), corticospinal tract (CST), IFOF, inferior longitudinal fasciculus (ILF), superior longitudinal fasciculus (SLF) [p < 0.05, false discovery rate (FDR) correction], and the pointwise analyses performed more sensitive. Furthermore, the negative correlations among MD, AD, RD, and symbol digit modalities test (SDMT) scores in the left TR (L_TR) were found in NMOSD. ConclusionPatients with NMOSD exhibited the specific nodes of WM fiber tract damage, which can enhance our understanding of WM microstructural abnormalities in NMOSD. In addition, the altered DTI metrics were correlated with cognitive impairment, which can be used as imaging markers for the early identification of NMOSD cognitive impairment."

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