The Role of DACT Family Members in Tumorigenesis and Tumor Progression

作者全名："Zeng, Yu; Zhang, Jiqin; Yue, Jianhe; Han, Guoqiang; Liu, Weijia; Liu, Lin; Lin, Xin; Zha, Yan; Liu, Jian; Tan, Ying"

作者地址："[Zeng, Yu; Han, Guoqiang; Liu, Jian; Tan, Ying] Guizhou Prov Peoples Hosp, Dept Neurosurg, Guiyang, Peoples R China; [Zhang, Jiqin] Guizhou Prov Peoples Hosp, Dept Anesthesiol, Guiyang, Peoples R China; [Lin, Xin; Zha, Yan] Guizhou Prov Peoples Hosp, Dept Nephrol, Guiyang, Peoples R China; [Yue, Jianhe] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 2, Chongqing, Peoples R China; [Liu, Weijia; Liu, Lin] Guizhou Prov Peoples Hosp, Dept Resp & Crit Care Med, Guiyang, Peoples R China"

通信作者："Liu, J; Tan, Y (通讯作者)，Guizhou Prov Peoples Hosp, Dept Neurosurg, Guiyang, Peoples R China.; Zha, Y (通讯作者)，Guizhou Prov Peoples Hosp, Dept Nephrol, Guiyang, Peoples R China."

来源：INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000828439300007

JCR分区：Q1

影响因子：9.2

年份：2022

卷号：18

期号：11

开始页：4532

结束页：4544

文献类型：Review

关键词：DACT family members; Cancer; Proliferation; Apoptosis; Invasion; Prognosis

摘要："Disheveled-associated antagonist of beta-catenin (DACT), which ubiquitously expressed in human tissue, is critical for regulating cell proliferation and several developmental processes in different cellular contexts. In addition, DACT is essential for some other cellular processes, such as cell apoptosis, migration and differentiation. Given the importance of DACT in these cellular processes, many scientists are gradually interested in studying the role of DACT in tumorigenesis and cancer progression. This review article focuses on the latest research regarding the essential functions and potential DACT mechanisms in the occurrence and progression of tumors. Our study indicates that DACT may act as a tumor biomarker for cancer diagnosis and prognosis, as well as a promising therapeutic target in cancers."

基金机构："National Natural Science Foundation of China [81960454, 81960344]; Guizhou Provincial Science and Technology Projects [[2020]1Z066]; Guizhou Provincial People's Hospital Doctor Foundation [[2018]06, [2018]03]; Guizhou Provincial People's Hospital National Science Foundation [GPPH-NSFC2019-13, GPPH-NSFC2019-17, GPPH-NSFC-D-2019-17]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (81960454, 81960344), the Guizhou Provincial Science and Technology Projects ([2020]1Z066), Guizhou Provincial People's Hospital Doctor Foundation ([2018]06 and [2018]03) and Guizhou Provincial People's Hospital National Science Foundation (GPPH-NSFC2019-13, 2019-17 and GPPH-NSFC-D-2019-17)."