Association between Blood Donation and Malignant and Benign Tumour Risk: A Population-Based Study of 3.4 Million Participants in China

作者全名："Su, Shu; Ma, Ting; Sun, Yang; Guo, Lingxia; Su, Xiaodong; Wang, Wenhua; Xie, Xinxin; Wang, Liqin; Xing, Lili; Zhang, Leilei; He, Shiyi; Yang, Jiangcun; Zhang, Lei"

作者地址："[Su, Shu; Ma, Ting; Wang, Wenhua; Xie, Xinxin; Wang, Liqin; Xing, Lili; Yang, Jiangcun; Zhang, Lei] Shaanxi Prov Peoples Hosp, Dept Transfus Med, Xian, Peoples R China; [Su, Shu] Chongqing Med Univ, Clin Res Management Off, Affiliated Hosp 2, Chongqing, Peoples R China; [Su, Shu; Zhang, Leilei; He, Shiyi; Zhang, Lei] Xi An Jiao Tong Univ, China Australia Joint Res Ctr Infect Dis, Sch Publ Hlth, Hlth Sci Ctr, Xian, Peoples R China; [Sun, Yang] Shaanxi Prov Peoples Hosp, Data Ctr, Xian, Peoples R China; [Guo, Lingxia] Hlth Commiss Shaanxi Prov, Planning Dev & Informat Off, Xian, Shaanxi, Peoples R China; [Su, Xiaodong] Shaanxi Prov Peoples Hosp, Dept Med Record Management, Xian, Peoples R China; [Zhang, Lei] Alfred Hlth, Artificial Intelligence & Modelling Epidemiol Prog, Melbourne Sexual Hlth Ctr, Melbourne, Australia; [Zhang, Lei] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou 450001, Henan, Peoples R China; [Zhang, Lei] Monash Univ, Fac Med, Cent Clin Sch, Melbourne, Australia"

通信作者："Yang, JC; Zhang, L (通讯作者)，Shaanxi Prov Peoples Hosp, Dept Transfus Med, Xian, Peoples R China.; Zhang, L (通讯作者)，Xi An Jiao Tong Univ, China Australia Joint Res Ctr Infect Dis, Sch Publ Hlth, Hlth Sci Ctr, Xian, Peoples R China.; Zhang, L (通讯作者)，Alfred Hlth, Artificial Intelligence & Modelling Epidemiol Prog, Melbourne Sexual Hlth Ctr, Melbourne, Australia.; Zhang, L (通讯作者)，Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou 450001, Henan, Peoples R China.; Zhang, L (通讯作者)，Monash Univ, Fac Med, Cent Clin Sch, Melbourne, Australia."

来源：JOURNAL OF ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000829463800001

JCR分区：Q2

影响因子：4.501

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："This study aims to identify the relationship between blood donation and malignant and benign tumour hospitalization risk. The cohort study was constructed in Shaanxi, China, to include blood donors and match nonblood donors one-to-one by gender, age, and county of residence. The study compared the hospitalization records of two groups from 2012 to 2018. A log-binomial regression model was used to estimate the relative risk (RR) of tumour risk between donors and nonblood donors among different age groups. A total of 1,625,599 donors were recruited (including 968,823 males) and compared with the matched nonblood donor group. Significantly lower risk of malignancy in males was found among donors (adjusted RR: 0.82, 95% CI: 0.75-0.92). Lower risks for specific types of tumours among donors were observed, including liver (0.42, [0.28-0.67]), lung (0.74, [0.59-0.87]), lymphoma (0.75, [0.62-0.85]), and oesophagus (0.55, [0.41-0.72]). However, the risk of brain cancer was higher among male donors (RR 1.19 [1.06-1.29]). Among female donors, lower risk of liver (0.57, [0.42-0.79]) and oesophagus malignancy (0.73, [0.62-0.88]) was observed. For benign tumours, male donors have a lower risk of benign skin tumour (0.79, [0.62-0.94]) and hemangioma and lymphangioma (0.75, [0.51-0.89]), while female donors have a lower risk in hemangioma and lymphangioma (0.65, [0.44-0.83]). We also found that the risk decreased with age among donors in the prevalence of tumours compared to that in nonblood donors (p < 0.05). Blood donation appears to be significantly associated with various tumour risks among both males and females. Overall, the risk of tumours decreased more substantially with age in blood donors compared with nonblood donors. Further research is warranted to investigate the impact of 'health donor effects' on these findings."

基金机构："2021 Science and Technology Talent Support Program of Shaanxi Provincial Peoples Hospital [2021LJ-14]; National Natural Science Foundation of China [81950410639]; Outstanding Young Scholars Support Program [3111500001]; Xian Jiaotong University Basic Research and Profession Grant [xtr022019003, xzy032020032]; Epidemiology Modeling and Risk Assessment [20200344]; Xian Jiaotong University Young Scholar Support Grant [YX6J004]; 2022 Science and Technology Talent Support Program of The Second Affiliated Hospital of ChongQing Medical University [2022sskyqdj]"

基金资助正文："The authors thank the following individuals at Shaanxi Provincial Blood Center: Hengxin Li, Xiaoli Cao, and Zhendong Sun. The authors also acknowledge the data interpretation assistance of Ke Ding at Hanzhong blood center, Bing Shi at Yanan blood center, Erqin Bai at Yulin blood center, Shengli Yan at Weinan blood center, Guoqiang Zhang at Tongchuan blood center, Hailin Zhang at Baoji blood center, Zhangxue Hu at Ankang blood center, Guancheng Yuan at Shangluo blood center, Xin liang at Xianyang blood center, and Keqian Cheng, Xiaoyun Gu, and Wenjie Wu at Shaanxi Health Information Center. Jiangcun Yang is supported by the 2021 Science and Technology Talent Support Program of Shaanxi Provincial Peoples Hospital (Grant no. 2021LJ-14). Lei Zhang was supported by the National Natural Science Foundation of China (Grant no. 81950410639), Outstanding Young Scholars Support Program (Grant no. 3111500001), Xian Jiaotong University Basic Research and Profession Grant (Grant nos. xtr022019003 and xzy032020032), Epidemiology Modeling and Risk Assessment (Grant no. 20200344), and Xian Jiaotong University Young Scholar Support Grant (Grant no. YX6J004). Shu Su was supported by the 2022 Science and Technology Talent Support Program of The Second Affiliated Hospital of ChongQing Medical University (Grant no. 2022sskyqdj)."