Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products

作者全名："Tan, Wei; Wang, Yunyan; Dai, Hongmei; Deng, Junhui; Wu, Zhifen; Lin, Lirong; Yang, Jurong"

作者地址："[Tan, Wei; Wang, Yunyan; Deng, Junhui; Wu, Zhifen; Lin, Lirong; Yang, Jurong] Chongqing Med Univ, Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China; [Dai, Hongmei] YunYang Cty Peoples Hosp, Nephrol, Chongqing, Peoples R China"

通信作者："Yang, JR (通讯作者)，Chongqing Med Univ, Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000830209900001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：cordyceps; renal fibrosis; Chinese herbal medicine; chronic kidney disease; mechanism

摘要："At present, there is no effective drug for the treatment of renal fibrosis; in particular, a safe and effective treatment for renal fibrosis should be established. Cordyceps has several medical effects, including immunoregulatory, antitumor, anti-inflammatory, and antioxidant effects, and may prevent kidney, liver, and heart diseases. Cordyceps has also been reported to be effective in the treatment of renal fibrosis. In this paper, we review the potential mechanisms of Cordyceps against renal fibrosis, focusing on the effects of Cordyceps on inflammation, oxidative stress, apoptosis, regulation of autophagy, reduction of extracellular matrix deposition, and fibroblast activation. We also discuss relevant published clinical trials and meta-analyses. Available clinical studies support the possibility that Cordyceps and related products provide benefits to patients with chronic kidney diseases as adjuvants to conventional drugs. However, the existing clinical studies are limited by low quality and significant heterogeneity. The use of Cordyceps and related products may be a potential strategy for the treatment of renal fibrosis. Randomized controlled trial studies with good methodological quality, favorable experimental design, and large sample size are needed to evaluate the efficacy and safety of Cordyceps."

基金机构：Chongqing Talent Program Project [cstc2021ycjh-bgzxm0090]

基金资助正文：This project is supported by the Chongqing Talent Program Project (cstc2021ycjh-bgzxm0090).