Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression

作者全名："Wei, Yuhan; Zhang, Jianwei; Fan, Xueke; Zheng, Zhi; Jiang, Xiaoyue; Chen, Dexi; Lu, Yuting; Li, Yingrui; Wang, Miao; Hu, Min; Du, Qi; Yang, Liuting; Li, Hongzhong; Xiao, Yi; Li, Yongfu; Jin, Jiangtao; Wang, Deying; Yuan, Xiangliang; Li, Qin"

作者地址："[Wei, Yuhan; Jiang, Xiaoyue; Lu, Yuting; Li, Yingrui; Wang, Miao; Hu, Min; Du, Qi; Li, Yongfu; Li, Qin] Capital Med Univ, Beijing Friendship Hosp, Clin Med Coll 2, Dept Oncol, Beijing, Peoples R China; [Zhang, Jianwei] Chinese Acad Med Sci Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Dept Pancreat & Gastr Surg, Beijing, Peoples R China; [Fan, Xueke] Jincheng Peoples Hosp, Gastroenterol Dept, Jincheng, Peoples R China; [Zheng, Zhi] Capital Med Univ, Beijing Friendship Hosp, Dept Gen Surg, Beijing, Peoples R China; [Chen, Dexi] Capital Med Univ, Beijing You Hosp, Beijing Inst Hepatol, Beijing, Peoples R China; [Hu, Min; Yang, Liuting] Shanxi Med Univ, Basic Med Coll, Biochem & Mol Biol, Taiyuan, Peoples R China; [Li, Hongzhong] Chongqing Med Univ, Affiliated Hosp 1, Chongqing Key Lab Mol Oncol & Epigenet, Chongqing, Peoples R China; [Xiao, Yi] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX USA; [Li, Yongfu] Hainan Med Univ, Affiliated Hosp 2, Dept Oncol, Haikou, Peoples R China; [Jin, Jiangtao] Zezhou Peoples Hosp, Dept Intervent Therapy, Jincheng, Peoples R China; [Wang, Deying] China Natl Nucl Corp CNNC, Hexin Informat Technol Beijing Co Ltd, Dept Technol Innovat, Beijing, Peoples R China; [Yuan, Xiangliang] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Lab Med, Shanghai, Peoples R China"

通信作者："Li, Q (通讯作者)，Capital Med Univ, Beijing Friendship Hosp, Clin Med Coll 2, Dept Oncol, Beijing, Peoples R China.; Yuan, XL (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Lab Med, Shanghai, Peoples R China."

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000830221900001

JCR分区：Q1

影响因子：7.3

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：immune profiling; gastric cancer; PD-1; biomarker; tumor immune microenvironment

摘要："The profiling of the tumor immune microenvironment (TIME) is critical for guiding immunotherapy strategies. However, how the composition of the immune landscape affects the tumor progression of gastric cancer (GC) is ill-defined. Here, we used mass cytometry to perform simultaneous in-depth immune profiling of the tumor, adjacent tissues, and blood cells from GC patients and revealed a unique GC tumor-immune signature, where CD8(+) T cells were present at a lower frequency in tumor tissues compared to adjacent tissues, whereas regulatory T cells and tumor-associated macrophages (TAMs) were significantly increased, indicating strong suppressive TIME in GC. Incorporated with oncogenic genomic traits, we found that the unique immunophenotype was interactively shaped by a specific GC gene signature across tumor progression. Earlier-stage GC lesions with IFN signaling enrichment harbored significantly altered T-cell compartments while advanced GC featured by metabolism signaling activation was accumulated by TAMs. Interestingly, PD-1 expression on CD8(+) T cells was relatively higher in earlier-stage GC patients, indicating that these patients may derive more benefits from PD-1 inhibitors. The dynamic properties of diverse immune cell types revealed by our study provide new dimensions to the immune landscape of GC and facilitate the development of novel immunotherapy strategies for GC patients."

基金机构："National Natural Science Foundation of China [81301912, 81772525]; Beijing Municipal Health and Scientific and Technological Achievements and Appropriate Technology Promotion Project [BHTPP202008]; ""High-value Patent Cultivation"" project of the Beijing Friendship Hospital Affiliated to the Capital Medical University [yyzscq202003]; Research Foundation of Beijing Friendship Hospital [yyqdkt2019-40]"

基金资助正文："This work was supported by the National Natural Science Foundation of China (81301912, 81772525), the Beijing Municipal Health and Scientific and Technological Achievements and Appropriate Technology Promotion Project (BHTPP202008), the ""High-value Patent Cultivation"" project of the Beijing Friendship Hospital Affiliated to the Capital Medical University (yyzscq202003), and the Research Foundation of Beijing Friendship Hospital (yyqdkt2019-40)."