Coronaviral Infection and Interferon Response: The Virus-Host Arms Race and COVID-19

作者全名："Liu, Qi; Chi, Sensen; Dmytruk, Kostyantyn; Dmytruk, Olena; Tan, Shuai"

作者地址："[Liu, Qi; Chi, Sensen; Tan, Shuai] Chongqing Med Univ, Sch Basic Med, Dept Immunol, Chongqing 400010, Peoples R China; [Liu, Qi] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA; [Dmytruk, Kostyantyn; Dmytruk, Olena] Natl Acad Sci Ukraine, Inst Cell Biol, Dept Mol Genet & Biotechnol, UA-79005 Lvov, Ukraine; [Dmytruk, Olena] Univ Rzeszow, Inst Biol & Biotechnol, PL-35601 Rzeszow, Poland"

通信作者："Liu, Q; Tan, S (通讯作者)，Chongqing Med Univ, Sch Basic Med, Dept Immunol, Chongqing 400010, Peoples R China.; Liu, Q (通讯作者)，Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA."

来源：VIRUSES-BASEL

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000831788300001

JCR分区：Q2

影响因子：4.7

年份：2022

卷号：14

期号：7

开始页：　

结束页：　

文献类型：Review

关键词：SARS-CoV-2; COVID-19; pattern-recognition receptor; PRR; interferon; innate immune; antiviral drug

摘要："The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in unprecedented morbidity and mortality worldwide. The host cells use a number of pattern recognition receptors (PRRs) for early detection of coronavirus infection, and timely interferon secretion is highly effective against SARS-CoV-2 infection. However, the virus has developed many strategies to delay interferon secretion and disarm cellular defense by intervening in interferon-associated signaling pathways on multiple levels. As a result, some COVID-19 patients suffered dramatic susceptibility to SARS-CoV-2 infection, while another part of the population showed only mild or no symptoms. One hypothesis suggests that functional differences in innate immune integrity could be the key to such variability. This review tries to decipher possible interactions between SARS-CoV-2 proteins and human antiviral interferon sensors. We found that SARS-CoV-2 actively interacts with PRR sensors and antiviral pathways by avoiding interferon suppression, which could result in severe COVID-19 pathogenesis. Finally, we summarize data on available antiviral pharmaceutical options that have shown potential to reduce COVID-19 morbidity and mortality in recent clinical trials."

基金机构：Science and Technology project affiliated to the education department of Chongqing municipality [KJQN202100436]; National Research Foundation of Ukraine [2020.01/0080]

基金资助正文：This work is supported by the Science and Technology project affiliated to the education department of Chongqing municipality (KJQN202100436) and National Research Foundation of Ukraine grant 2020.01/0080.