Efficacy and safety of focused low-intensity pulsed ultrasound versus pulsed shortwave diathermy on knee osteoarthritis: a randomized comparative trial

作者全名："Jia, Lang; Li, Dongqian; Wei, Xia; Chen, Jinyun; Zuo, Deyu; Chen, Wenzhi"

作者地址："[Jia, Lang; Li, Dongqian; Wei, Xia] Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 2, Chongqing, Peoples R China; [Chen, Jinyun; Chen, Wenzhi] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China; [Zuo, Deyu] Chongqing Tradit Chinese Med Hosp, Dept Rehabil, Chongqing, Peoples R China; [Chen, Wenzhi] Chongqing Med Univ, Clin Ctr Tumor Therapy, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Jia, L (通讯作者)，Chongqing Med Univ, Dept Rehabil Med, Affiliated Hosp 2, Chongqing, Peoples R China.; Chen, WZ (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China.; Chen, WZ (通讯作者)，Chongqing Med Univ, Clin Ctr Tumor Therapy, Affiliated Hosp 2, Chongqing, Peoples R China."

来源：SCIENTIFIC REPORTS

ESI学科分类：Multidisciplinary

WOS号：WOS:000831887000048

JCR分区：Q2

影响因子：4.6

年份：2022

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："The aim of this study was to compare the efficacy and safety of focused low-intensity pulsed ultrasound (FLIPUS) with pulsed shortwave diathermy (PSWD) in subjects with painful knee osteoarthritis (OA). In a prospective randomized trial, 114 knee OA patients were randomly allocated to receive FLIPUS or PSWD therapy. The primary outcome was the change from baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total scores. Secondary outcomes included the numerical rating scale (NRS) for pain assessment, time up and go ( TUG) test, active joint range of motion (ROM) test, and Global Rating of Change (GRC) scale. Data were collected at baseline, 12 days, 12 weeks and 24 weeks. Patients receiving FLIPUS therapy experienced significantly greater improvements in the WOMAC total scores than patients receiving PSWD therapy at 12 days (mean difference, - 10.50; 95% CI - 13.54 to - 7.45; P = 0.000). The results of the NRS, TUG test, ROM test and GRC scale showed that participants treated with FLIPUS reported less pain and better physical function and health status than those treated with PSWD at 12 days (P = 0.011, P = 0.005, P = 0.025, P = 0.011, respectively). Furthermore, patients in the FLIPUS group showed significant improvements in the WOMAC total scores and NRS scores at 12 weeks (mean difference, - 7.57; 95% CI - 10.87 to - 4.26; P = 0.000 and - 1.79; 95% CI - 2.11 to - 1.47, respectively) and 24 weeks (mean difference, - 6.96; 95% CI - 10.22 to - 3.71; P = 0.000 and - 1.37; 95% CI - 1.64 to - 0.96; P = 0.000, respectively) of follow-up. There were no adverse events during or after the interventions in either group. This study concluded that both FLIPUS and pulsed SWD are safe modalities, and FLIPUS was more effective than PSWD in alleviating pain and in improving dysfunction and health status among subjects with knee OA in the short term."

基金机构：National Natural Science Foundation of China [81802234]; Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0134]; Traditional Chinese Medicine Science and Technology Project of Chongqing [ZY201802104]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文："The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported in part by the National Natural Science Foundation of China (Grant No. 81802234), the Natural Science Foundation of Chongqing (Grant No. cstc2020jcyj-msxmX0134), and the Traditional Chinese Medicine Science and Technology Project of Chongqing (Grant No. ZY201802104). Lang Jia was supported by the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."