Effects of Autologous Platelet-Rich Plasma on Healing of Peptic Ulcers: A Randomized Controlled Trial
作者全名："Xu, Ting; Tian, Yin; Wang, Yi; Yi, Zhongmei; Li, Chenchen; Wang, Shichun; Fan, Yahan; Yao, Chunyan; Peng, Guiyong; Lu, Hua"
作者地址："[Xu, Ting; Yi, Zhongmei; Li, Chenchen; Wang, Shichun; Fan, Yahan; Yao, Chunyan; Lu, Hua] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Blood Transfus, Chongqing, Peoples R China; [Tian, Yin; Peng, Guiyong] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Gastroenterol, Chongqing, Peoples R China; [Wang, Yi] Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Rehabil Med, Chongqing, Peoples R China; [Lu, Hua] Second Affiliated Hosp Chongqing Med Univ, Dept Blood Transfus, Chongqing, Peoples R China"
通信作者："Lu, H (通讯作者)，Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Blood Transfus, Chongqing, Peoples R China.; Peng, GY (通讯作者)，Third Mil Med Univ, Army Med Univ, Southwest Hosp, Dept Gastroenterol, Chongqing, Peoples R China.; Lu, H (通讯作者)，Second Affiliated Hosp Chongqing Med Univ, Dept Blood Transfus, Chongqing, Peoples R China."
来源：GASTROENTEROLOGY RESEARCH AND PRACTICE
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:000831919000001
JCR分区：Q4
影响因子：2
年份：2022
卷号：2022
期号：
开始页：
结束页：
文献类型：Article
关键词：
摘要："Purpose. Peptic ulcer is a multifactorial and complex disease and affects a wide range of people worldwide. We provided a novel therapeutic approach for peptic ulcer and observed its effect. Methods. Peptic ulcer patients were enrolled from 2016 to 2017 in Chongqing and randomly assigned to two groups: a control group that used only rabeprazole and a platelet-rich plasma (PRP) group that received a combination therapy of autologous PRP (aPRP) and rabeprazole. The therapeutic effect was assessed via the ulcer size and symptom score. Results. A total of 27 patients were included (12 patients in the control group and 15 patients in the PRP group) in this study. Our results showed that all participants have healed in 30 days, and there was no significant difference in healing time between the PRP group and the control group in different independent variables. However, regression analysis revealed that the healing time was 6.99 days shorter in the PRP group than that in the control group, and patients with higher symptom scores in the initial examination need more time to heal during treatment. Endoscopic results showed that the repaired ulcer in the PRP group was more similar to the normal gastric mucosa tissue than that the control group. Conclusion. This study showed an encouraging preliminary result that aPRP has a positive result in patients with peptic ulcer and seems to be a better choice for refractory peptic ulcer treatment. Although further follow-up studies are needed to determine the duration of efficacy of aPRP, the approach will be helpful in improving the clinical treatment of peptic ulcer."
基金机构：Clinical Technology Innovation Cultivation Program of Third Military Medical University [CX2019JS103]; Social Livelihood and Technology Innovation Projects of Chongqing [cstc2016shmszx130020]
基金资助正文："This study was supported by the Clinical Technology Innovation Cultivation Program of Third Military Medical University (CX2019JS103) and the Social Livelihood and Technology Innovation Projects of Chongqing (cstc2016shmszx130020). The authors are grateful to all of the participants in this study for their support during this study. Additionally, we are grateful to the ISBT for giving us an opportunity to present this manuscript as a meeting abstract in the 29th Regional Congress."
