Altered brain activation during reward anticipation in bipolar disorder

作者全名："Long, Xipeng; Wang, Xiuli; Tian, Fangfang; Cao, Yuan; Xie, Hongsheng; Jia, Zhiyun"

作者地址："[Long, Xipeng; Cao, Yuan; Xie, Hongsheng; Jia, Zhiyun] Sichuan Univ, Dept Nucl Med, West China Hosp, 37 GuoXue Xiang, Chengdu, Sichuan, Peoples R China; [Wang, Xiuli] Fourth Peoples Hosp Chengdu, Dept Clin Psychiat, Chengdu, Sichuan, Peoples R China; [Tian, Fangfang] Chongqing Med Univ, Dept Nucl Med, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Jia, ZY (通讯作者)，Sichuan Univ, Dept Nucl Med, West China Hosp, 37 GuoXue Xiang, Chengdu, Sichuan, Peoples R China."

来源：TRANSLATIONAL PSYCHIATRY

ESI学科分类：PSYCHIATRY/PSYCHOLOGY

WOS号：WOS:000832714700001

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：12

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Although altered reward sensitivity has been observed in individuals with bipolar disorder (BD), the brain function findings related to reward processing remain unexplored and inconsistent. This meta-analysis aimed to identify brain activation alterations underlying reward anticipation in BD. A systematic literature research was conducted to identify fMRI studies of reward-relevant tasks performed by BD individuals. Using Anisotropic Effect Size Signed Differential Mapping, whole-brain and ROI of the ventral striatum (VS) coordinate-based meta-analyses were performed to explore brain regions showing anomalous activation in individuals with BD compared to healthy controls (HC), respectively. A total of 21 studies were identified in the meta-analysis, 15 of which were included in the whole-brain meta-analysis and 17 in the ROI meta-analysis. The whole-brain meta-analysis revealed hypoactivation in the bilateral angular gyrus and right inferior frontal gyrus during reward anticipation in individuals with BD compared to HC. No significant activation differences were observed in bilateral VS between two groups by whole-brain or ROI-based meta-analysis. Individuals with BD type I and individuals with euthymic BD showed altered activation in prefrontal, angular, fusiform, middle occipital gyrus, and striatum. Hypoactivation in the right angular gyrus was positively correlated with the illness duration of BD. The present study reveals the potential neural mechanism underlying impairment in reward anticipation in BD. Some clinical features such as clinical subtype, mood state, and duration of illness confound the underlying neurobiological abnormality reward anticipation in BD. These findings may have implications for identifying clinically relevant biomarkers to guide intervention strategies for BD."

基金机构："National Natural Science Foundation of China [81971595, 81771812]; Key Program of the National Natural Science Foundation of Sichuan Province [2022NSFSC0047]; BULL;5 Project for Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University [2020HXFH005]"

基金资助正文："This study was supported by the National Natural Science Foundation of China (Grant Nos. 81971595 and 81771812), the Key Program of the National Natural Science Foundation of Sichuan Province (Grant No. 2022NSFSC0047), and the 1 center dot 3 center dot 5 Project for Disciplines of Excellence-Clinical Research Incubation Project, West China Hospital, Sichuan University (Grant No. 2020HXFH005)."