Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis

作者全名："Luo, Minghao; Hu, Yu; Lv, Dingyi; Xie, Lingyun; Yang, Shenglan; Zuo, Deyu; Xue, Yuzhou; He, An"

作者地址："[Luo, Minghao; Hu, Yu; Lv, Dingyi; Xie, Lingyun; Yang, Shenglan; Xue, Yuzhou; He, An] Chongqing Med Univ, Div Cardiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Zuo, Deyu] Chongqing Tradit Chinese Med Hosp, Dept Rehabil Med, Chongqing, Peoples R China"

通信作者："He, A (通讯作者)，Chongqing Med Univ, Div Cardiol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000835068600003

JCR分区：Q2

影响因子：7.31

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background. Hypoglycemia is a dangerous side effect of intensive glucose control in diabetes. Even though it leads to adverse cardiovascular events, the effects of hypoglycemia on vascular biology in diabetes have not been adequately studied. Methods. Aged Sprague-Dawley rats were fed a high-fat diet and given streptozotocin to induce type 2 diabetes mellitus (T2DM). Acute and recurrent hypoglycemia were then induced by glucose via insulin administration. Vascular function, oxidative stress, and pyroptosis levels in aortic tissue were assessed by physiological and biochemical methods. Results. Hypoglycemia was associated with a marked decrease in vascular function, elevated oxidative stress, and elevated pyroptosis levels in the thoracic aorta. The changes in oxidative stress and pyroptosis were greater in rats with recurrent hypoglycemia than in those with acute hypoglycemia. Conclusions. Hypoglycemia impaired vascular function in aged rats with T2DM by inducing pyroptosis. The extent of injury increased with the duration of blood glucose fluctuation."

基金机构：Innovation Program for Doctoral Student of the First Affiliated Hospital of Chongqing Medical University [CYYY-BSYJSCXXM-202202]

基金资助正文：AcknowledgmentsThis work was supported by An He and the Innovation Program for Doctoral Student of the First Affiliated Hospital of Chongqing Medical University (CYYY-BSYJSCXXM-202202).