Modification effect of changes in cardiometabolic traits in association between kidney stones and cardiovascular events

作者全名："Xu, Min; Zhao, Zhiyun; Shen, Feixia; Hu, Ruying; Lu, Jieli; Xu, Yu; Wang, Tiange; Li, Mian; Chen, Gang; Chen, Li; Chen, Lulu; Chen, Yuhong; Deng, Huacong; Gao, Zhengnan; Huo, Yanan; Li, Qiang; Liu, Chao; Luo, Zuojie; Mu, Yiming; Qin, Guijun; Qin, Yingfen; Shi, Lixin; Su, Qing; Wan, Qin; Wang, Guixia; Wang, Shuangyuan; Wang, Youmin; Wu, Shengli; Xu, Yiping; Yan, Li; Yang, Tao; Ye, Zhen; Yu, Xuefeng; Zhang, Yinfei; Zhao, Jiajun; Zeng, Tianshu; Wang, Weiqing; Bi, Yufang; Tang, Xulei; Ning, Guang"

作者地址："[Xu, Min; Zhao, Zhiyun; Lu, Jieli; Xu, Yu; Wang, Tiange; Li, Mian; Chen, Yuhong; Wang, Shuangyuan; Wang, Weiqing; Bi, Yufang; Ning, Guang] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China; [Xu, Min; Zhao, Zhiyun; Lu, Jieli; Xu, Yu; Wang, Tiange; Li, Mian; Chen, Yuhong; Wang, Shuangyuan; Wang, Weiqing; Bi, Yufang; Ning, Guang] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Natl Clin Res Ctr Metab Dis, Key Lab Endocrine & Metab Dis Natl Hlth Commiss PR, Shanghai, Peoples R China; [Shen, Feixia] Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 1, Wenzhou, Peoples R China; [Hu, Ruying; Ye, Zhen] Inst Chron Dis, Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China; [Chen, Gang] Fujian Med Univ, Fujian Prov Hosp, Dept Endocrinol, Fuzhou, Peoples R China; [Chen, Li] Shandong Univ, Dept Endocrinol, Qilu Hosp, Jinan, Peoples R China; [Chen, Lulu; Zeng, Tianshu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China; [Deng, Huacong] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Chongqing, Peoples R China; [Gao, Zhengnan] Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian, Peoples R China; [Huo, Yanan] Nanchang Univ, Dept Endocrinol, Jiangxi Prov Peoples Hosp, Nanchang, Peoples R China; [Li, Qiang] Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 1, Harbin, Peoples R China; [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Dept Endocrinol, Nanjing, Peoples R China; [Luo, Zuojie] Guangxi Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanning, Peoples R China; [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China; [Qin, Guijun] Zhengzhou Univ, Dept Endocrinol, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Qin, Yingfen] Guangxi Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanning, Peoples R China; [Shi, Lixin] Guiyang Med Coll, Dept Endocrinol, Affiliated Hosp, Guiyang, Peoples R China; [Su, Qing] Shanghai Jiao Tong Univ, Dept Endocrinol, Xinhua Hosp, Sch Med, Shanghai, Peoples R China; [Wan, Qin] Southwest Med Univ, Dept Endocrinol, Affiliated Hosp, Luzhou, Peoples R China; [Wang, Guixia] First Hosp Jilin Univ, Dept Endocrinol, Changchun, Peoples R China; [Wang, Youmin] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, Hefei, Peoples R China; [Wu, Shengli] Karamay Municipal Peoples Hosp, Dept Endocrinol, Karamay, Xinjiang, Peoples R China; [Xu, Yiping] Shanghai Jiao Tong Univ, Clin Trials Ctr, Ruijin Hosp, Sch Med, Shanghai, Peoples R China; [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol, Guangzhou, Peoples R China; [Yang, Tao] Nanjing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanjing, Peoples R China; [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China; [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Dept Endocrinol, Shanghai, Peoples R China; [Zhao, Jiajun] Shandong Univ, Dept Endocrinol, Shandong Prov Hosp, Jinan, Peoples R China; [Tang, Xulei] Lanzhou Univ, Dept Endocrinol, Hosp 1, Lanzhou, Peoples R China"

通信作者："Wang, WQ; Bi, YF; Ning, G (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China.; Wang, WQ; Bi, YF; Ning, G (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Natl Clin Res Ctr Metab Dis, Key Lab Endocrine & Metab Dis Natl Hlth Commiss PR, Shanghai, Peoples R China.; Tang, XL (通讯作者)，Lanzhou Univ, Dept Endocrinol, Hosp 1, Lanzhou, Peoples R China."

来源：FRONTIERS IN CARDIOVASCULAR MEDICINE

ESI学科分类：　

WOS号：WOS:000838298400001

JCR分区：Q2

影响因子：3.6

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：kidney stone; CVD; metabolic disorders; modification effect; longitudinal change

摘要："BackgroundsWhether longitudinal changes in metabolic status influence the effect of kidney stones on cardiovascular disease (CVD) remains unclarified. We investigated the modification effect of status changes in metabolic syndrome (MetS) in the association of kidney stones with risk of incident CVD events. MethodsWe performed a prospective association and interaction study in a nationwide cohort including 129,172 participants aged >= 40 years without CVDs at baseline and followed up for an average of 3.8 years. Kidney stones information was collected by using a questionnaire and validated by medical records. The repeated biochemical measurements were performed to ascertain the metabolic status at both baseline and follow-up. Results4,017 incident total CVDs, 1,413 coronary heart diseases (CHDs) and 2,682 strokes were documented and ascertained during follow-up. Kidney stones presence was significantly associated with 44%, 70% and 31% higher risk of CVDs, CHDs and stroke, respectively. The stratified analysis showed significant associations were found in the incident and sustained MetS patients, while no significant associations were found in the non-MetS at both baseline and follow-up subjects or the MetS remission ones, especially in women. For the change status of each single component of the MetS, though the trends were not always the same, the associations with CVD were consistently significant in those with sustained metabolic disorders, except for the sustained high blood glucose group, while the associations were consistently significant in those with incident metabolic disorders except for the incident blood pressure group. We also found a significant association of kidney stone and CVD or CHD risk in the remain normal glucose or triglycerides groups; while the associations were consistently significant in those with incident metabolic disorders except for the incident blood pressure group. We also found a significant association of kidney stone and CVD or CHD risk in the remain normal glucose or triglycerides groups. ConclusionsA history of kidney stones in women with newly developed MetS or long-standing MetS associated with increased risk of CVD. The mechanisms link kidney stones and CVD risk in the metabolic and non-metabolic pathways were warranted for further studies."

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