CT findings of Talaromyces marneffei infection among HIV patients with lymphadenopathy

作者全名："Zhu, Xiao-ling; Tang, Guang-Xiao; Liu, Xue-yan; Li, Ran; Lv, Sheng-xiu; Wang, Guang-xian"

作者地址："[Zhu, Xiao-ling; Li, Ran; Wang, Guang-xian] Chongqing Med Univ, Banan Peoples Hosp, Dept Radiol, Chongqing, Peoples R China; [Tang, Guang-Xiao; Liu, Xue-yan; Lv, Sheng-xiu] Chongqing Publ Hlth Med Ctr, Dept Radiol, Chongqing, Peoples R China"

通信作者："Wang, GX (通讯作者)，Chongqing Med Univ, Banan Peoples Hosp, Dept Radiol, Chongqing, Peoples R China.; Lv, SX (通讯作者)，Chongqing Publ Hlth Med Ctr, Dept Radiol, Chongqing, Peoples R China."

来源：FRONTIERS IN MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000838628900001

JCR分区：Q2

影响因子：3.9

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：HIV; AIDS; Talaromyces marneffei; computed tomography; lymph node; diagnosis

摘要："BackgroundTalaromyces marneffei (T. marneffei) is an opportunistic fungal pathogen commonly found in human immunodeficiency virus (HIV) patients that often infects lymph nodes. Knowledge about the computed tomography (CT) characteristics of T. marneffei lymphadenopathy in HIV patients is limited. The aim of this study was to investigate the clinical and CT characteristics of T. marneffei lymphadenopathy to improve its diagnosis and promote recognition of this type of infection in radiology. MethodsBetween February 2019 and June 2021, we retrospectively reviewed the clinical features and CT characteristics of T. marneffei lymphadenopathy in 21 HIV patients. ResultsThe clinical symptoms of T. marneffei infection are non-specific. Anemia (100%), fever (85.7%) and cough and sputum production (76.2%) were the most frequent symptoms. Multiple lymphadenopathies, mainly in the mediastinum (76.2%) and mesentery (82.4%), can be fused (14.3%) and necrotic (52.4%), with slight (41.7%) and moderate enhancement (58.3%) that is heterogeneous. In addition to involving the lymph nodes, the lesions involved the lungs (81.0%), liver and spleen (42.9%), and small intestine (14.3%). ConclusionsT. marneffei is prone to affecting lymph nodes and extranodal organs in HIV patients. Although the clinical manifestations of T. marneffei infection are not specific, the possibility of T. marneffei infection should be considered if CT findings indicate multiple lesion sites."

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