Biomimetic macrophage membrane-coated gold-quantum dots with tumor microenvironment stimuli-responsive capability for tumor theranostic

作者全名："Wang, Fan; Yu, Qinghua; Li, Jia; Jiang, Junhao; Deng, Tao; Yu, Chao"

作者地址："[Wang, Fan; Yu, Qinghua; Li, Jia; Deng, Tao; Yu, Chao] Chongqing Med Univ, Coll Pharm, Res Ctr Pharmaceut Preparat & Nanomed, Chongqing 40016, Peoples R China; [Jiang, Junhao] Chongqing Med Univ, Coll Pharm, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 40016, Peoples R China; [Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 40016, Peoples R China; [Deng, Tao] Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 40016, Peoples R China"

通信作者："Deng, T; Yu, C (通讯作者)，Chongqing Med Univ, Coll Pharm, Res Ctr Pharmaceut Preparat & Nanomed, Chongqing 40016, Peoples R China.; Deng, T (通讯作者)，Chongqing Med Univ, Coll Pharm, Chongqing Pharmacodynam Evaluat Engn Technol Res C, Chongqing 40016, Peoples R China."

来源：MATERIALS TODAY BIO

ESI学科分类：　

WOS号：WOS:000843481000003

JCR分区：Q1

影响因子：8.2

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Carbon dots; Gold nanoparticle; Inter-particle assembly; Tumor microenvironment; Theranostic

摘要："Tumor microenvironment (TME) is intently related to tumor growth, progression and invasion, leading to drug resistance and insufficient therapeutic efficacy. However, remodeling TME and utilizing TME for exploring intelligent nanomaterials that can realize tumor theranostic is still challenging. Nowadays, the theranostic based on chemotherapy exposes some deficiencies, such as low targeting, weak permeability and premature clearance. Furthermore, it is challenging to cure drug-resistant tumors effectively. For the sake of solving these problems, a biomimetic decomposable nano-theranostic (MMV-Au-CDs-DOX) was well-established in this work. The Au-CDs are coated with macrophage-derived microvesicle to realize drug release accurately and enhance the biocom-patibility of internal nanoparticles. Furthermore, MMV-Au-CDs-DOX would locate in the inflammation position of tumor, and disintegrate correspondingly into pieces with certain different functions stimulated by TME. Subse-quently, the released anti-tumor nanodrugs were used for multimodal therapy, including chemotherapy and hemodynamic therapy. In addition, combined with the ability of Au-CDs to recognize GSH specifically, the off-on fluorescent probe was constructed to monitor the GSH of tumor cells and provided information on chemotherapy resistance."

基金机构："China Postdoctoral Sci- ence Foundation [2019M653356]; Chongqing Postdoctoral Science Foundation [cstc2019jcyjbshX0060]; Introduction Teachers Foundation of Chongqing Medical University [YXY2018BSH1, YXY2019BSH2]"

基金资助正文："Acknowledgements This work was fi nancially supported by the China Postdoctoral Sci- ence Foundation (2019M653356) , Chongqing Postdoctoral Science Foundation (cstc2019jcyjbshX0060) , and the Introduction Teachers Foundation of Chongqing Medical University (YXY2018BSH1 and YXY2019BSH2) ."