"Relationship between serum parathyroid hormone levels and abdominal aortic calcification in patients starting hemodialysis who have never taken calcium tablets, calcitriol, or vitamin D analogs"

作者全名："He, Jin; Sun, Xiaoyan; Nie, Rongjian; Zhao, Lin"

作者地址："[He, Jin; Sun, Xiaoyan; Nie, Rongjian] Chongqing Univ Posts & Telecommun, Div Nephrol & Endocrinol, Chonggang Gen Hosp, Chongqing, Peoples R China; [Zhao, Lin] Chongqing Med Univ, Dept Emergency & Crit Care Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China"

通信作者："Zhao, L (通讯作者)，Chongqing Med Univ, Dept Emergency & Crit Care Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China."

来源：RENAL FAILURE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000844202300001

JCR分区：Q2

影响因子：3

年份：2022

卷号：44

期号：1

开始页：1409

结束页：1416

文献类型：Article

关键词：Chronic kidney disease; vascular calcification; parathyroid hormone; abdominal aortic calcification

摘要："Background Vascular calcification (VC) and secondary hyperparathyroidism (SHPT) are important causes of the high incidence of cardiovascular events in chronic kidney disease (CKD) patients. The relationship between parathyroid hormone (PTH) and VC is very complex. The aim of this study was to determine the correlation between PTH levels and abdominal aortic calcification (AAC) in patients starting hemodialysis who had not received calcium tablets, calcium-containing phosphorus binders, calcitriol, or vitamin D analogs. Methods Seventy-one patients were included. Latero-lateral X-ray lumbar radiography, serum intact PTH (iPTH) levels, and predialysis biochemical parameters were obtained. The degree of AAC was evaluated according to the methods described previously by Kauppila et al. Results We found that there was a strong negative correlation between serum PTH and AAC (Spearman's rho -0.76, p < 0.001). Receiver operating characteristic (ROC) curve analysis showed that low serum PTH level could predict the presence and extent of AAC (area under the curve values were 0.9013 [p < 0.0001] and 0.780 [p = 0.0041], respectively). Conclusions Our results indicate that serum PTH level is significantly negatively correlated with AAC within a certain concentration range in patients starting hemodialysis who had not received calcium tablets, calcium-containing phosphorus binders, calcitriol, or vitamin D analogs."

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