"Cerebral blood flow in adolescents with drug-naive, first-episode major depressive disorder: An arterial spin labeling study based on voxel-level whole-brain analysis"

作者全名："Xiong, Ying; Chen, Rong-Sheng; Wang, Xing-Yu; Li, Xiao; Dai, Lin-Qi; Yu, Ren-Qiang"

作者地址："[Xiong, Ying; Chen, Rong-Sheng; Wang, Xing-Yu; Yu, Ren-Qiang] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Xiong, Ying] Chongqing Gen Hosp, Dept Hematol, Chongqing, Peoples R China; [Li, Xiao; Dai, Lin-Qi] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Yu, RQ (通讯作者)，Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000844566100001

JCR分区：Q2

影响因子：4.3

年份：2022

卷号：16

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：major depressive disorder; adolescent; arterial spin labeling; regional cerebral blood flow; fMRI

摘要："PurposeThe major depressive disorder (MDD) can be a threat to the health of people all over the world. Although governments have developed and implemented evidence-based interventions and prevention programs to prevent MDD and maintain mental health in adolescents, the number of adolescents with this condition has been on the rise for the past 10 years. MethodsA total of 60 adolescents were recruited, including 32 drug-naive adolescents with first-episode MDD and 28 healthy controls (HCs). Alterations in the intrinsic cerebral activity of the adolescents with MDD were explored using arterial spin labeling (ASL) while differences in the regional cerebral blood flow (rCBF) of the two groups were assessed based on voxel-based whole-brain analysis. Finally, correlations between the regional functional abnormalities and clinical variables were investigated for adolescents with MDD. ResultsCompared with HCs, MDD patients had a lower rCBF in the left triangular part of the inferior frontal gyrus (IFGtriang) but a higher one in the right Precental gyrus (PreCG). Negative correlations were also noted between the CBF in the left IFGtriang and the Hamilton depression scale (HAMD) scores of MDD patients. ConclusionElucidating the neurobiological features of adolescent patients with MDD is important to adequately develop methods that can assist in early diagnosis, precaution and intervention."

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