Preoperative estimation of the survival of patients with unresectable hepatocellular carcinoma achieving complete response after conventional transcatheter arterial chemoembolization: assessments of clinical and LI-RADS MR features

作者全名："Song, Wenlong; Chen, Qianyu; Guo, Dajing; Jiang, Caiming"

作者地址："[Song, Wenlong; Jiang, Caiming] Ninth People Hosp Chongqing, Dept Radiol, 69 Jialing Village, Chongqing 400010, Peoples R China; [Chen, Qianyu] Ninth People Hosp Chongqing, Dept Ultrasonog, Chongqing, Peoples R China; [Song, Wenlong; Guo, Dajing] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Jiang, CM (通讯作者)，Ninth People Hosp Chongqing, Dept Radiol, 69 Jialing Village, Chongqing 400010, Peoples R China."

来源：RADIOLOGIA MEDICA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000844911000002

JCR分区：Q1

影响因子：8.9

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Hepatocellular carcinoma; Survival; Liver Imaging Reporting and Data System and transcatheter arterial chemoembolization

摘要："Purpose To identify the associations of clinical and magnetic resonance (MR) features with overall survival (OS) in patients with unresectable hepatocellular carcinoma (HCC) achieving complete response (CR) after conventional transcatheter arterial chemoembolization (TACE) and to further develop an individual nomograph to estimate the survival probability. Materials and methods A total of 112 patients with unresectable HCC treated with TACE as first-line treatment were retrospectively evaluated. Potential risk factors associated with OS were identified by univariate and multivariate Cox analyses. The survival model was developed by multivariate Cox proportional hazard model. The area under the receiver operating characteristic curve was calculated to assess the performance of each marker and of the whole model. Discrimination was performed using Kaplan-Meier curves, and the survival curves were compared by the log-rank test. A nomogram derived from the survival model was established. Results Multivariate Cox analyses indicated that nonsmooth tumor margin, peritumoral enhancement, fat sparing in solid mass, and Barcelona clinic liver cancer (BCLC) stage were independent risk indicators associated with OS. The survival model showed acceptable diagnostic power, with an area under the curve (AUC) of 0.687. Kaplan-Meier curves demonstrated that the model discriminated well, as the high-risk and low-risk groups had median survival times of 21.6 months and 34.8 months, respectively (log-rank test, P = 0.01). Conclusions Nonsmooth tumor margin, peritumoral enhancement, fat sparing in solid mass, and BCLC stage were potential biomarkers to evaluate the survival with favorable performance and discriminate HCC patients with CR under conventional TACE treatment."

基金机构："Medical Scientific Research Joint Project of Chongqing Health Commission and Science and Technology Bureau in China [2022MSXM071, 2022MSXM022]"

基金资助正文："TThis work was supported by the Medical Scientific Research Joint Project of Chongqing Health Commission and Science and Technology Bureau in China (Grant: 2022MSXM071, 2022MSXM022)."