"Prevalent vertebral fractures among urban-dwelling Chinese postmenopausal women: a population-based, randomized-sampling, cross-sectional study"

作者全名："Xia, Weibo; Liu, Qiang; Lv, Jinhan; Zhang, Zhenlin; Wu, Wen; Xie, Zhongjian; Chen, Jianting; He, Liang; Dong, Jian; Hu, Zhenming; Lin, Qiang; Yu, Wei; Wei, Fang; Wang, Jue"

作者地址："[Xia, Weibo] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol,Natl Commiss Hlth, Key Lab Endocrinol,State Key Lab Complex Severe &, Beijing, Peoples R China; [Liu, Qiang] Shanxi Dayi Hosp, Taiyuan, Shanxi, Peoples R China; [Lv, Jinhan] Peoples Hosp Ningxia Hui Autonomous Reg, Yinchuan, Ningxia, Peoples R China; [Zhang, Zhenlin] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Osteoporosis & Bone Dis, Shanghai, Peoples R China; [Wu, Wen] Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China; [Xie, Zhongjian] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Hunan Prov Key Lab Metab Bone Dis, 139 Middle Renmin Rd, Changsha, Hunan, Peoples R China; [Xie, Zhongjian] Cent South Univ, Xiangya Hosp 2, Dept Metab & Endocrinol, 139 Middle Renmin Rd, Changsha, Hunan, Peoples R China; [Chen, Jianting] Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Spine Surg, Guangzhou, Peoples R China; [He, Liang] Beijing Jishuitan Hosp, Beijing, Peoples R China; [Dong, Jian] Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China; [Hu, Zhenming] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China; [Lin, Qiang; Yu, Wei] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China; [Wei, Fang] Organon China, Med Affairs & Outcomes Res, Shanghai, Peoples R China; [Wang, Jue] MSD China, Merck Res Labs, Global Med & Sci Affairs, Shanghai, Peoples R China"

通信作者："Xia, WB (通讯作者)，Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol,Natl Commiss Hlth, Key Lab Endocrinol,State Key Lab Complex Severe &, Beijing, Peoples R China.; Liu, Q (通讯作者)，Shanxi Dayi Hosp, Taiyuan, Shanxi, Peoples R China."

来源：ARCHIVES OF OSTEOPOROSIS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000850792600001

JCR分区：Q2

影响因子：3

年份：2022

卷号：17

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Prevalent vertebral fractures; Osteoporosis; Randomized sampling; Postmenopausal women; Community-dwelling

摘要："A Summary In this population-based, cross-sectional study, we investigated vertebral fracture (VF) prevalence among Chinese postmenopausal women. We found 14.7% of population had VFs, which increased with age. Age >= 65 years, hip fracture, and densitometric osteoporosis were significantly associated with VFs. The prevalence of osteoporosis was remarkably high. Purpose To investigate VF prevalence among Chinese postmenopausal women in this population-based, randomized-sampling, cross-sectional study. Methods The investigator obtained lists of women from communities. Randomization was performed using SAS programming based on age group in each region. Postmenopausal women aged >= 50 years in the urban community were included. The investigator interviewed subjects to collect self-reported data and measured BMD. Spine radiographs were adjudicated by Genant's semi-quantitative method. VFs were defined as fractures of at least one vertebra classified by Genant's score 1-3 and were analyzed using descriptive statistics. Results A total of 31,205 women listed for randomized sampling from 10 Tier-3 hospitals at 5 regions. Of 2634 women in the full analysis set, 14.7% (388/2634, 95% CI: 13.4, 17.1) had prevalent VFs. VF prevalence increased with age (Cochran- Armitage test p < 0.0001) and was significantly higher in women aged >= 65. VF prevalence did not differ between North (14.4%, 95% CI: 12.5, 16.4) and South China (15.1%, 95% CI: 13.3, 17.1). In women with no prior VFs, prevalent VFs were 12.4% (95% CI: 11.2, 13.7). Age >= 65 years (OR: 2.57, 95% CI: 1.91, 3.48), hip fracture (OR: 2.28, 95% CI: 1.09, 4.76), and densitometric osteoporosis (OR: 2.52, 95% CI: 1.96, 3.22) were significantly associated with prevalent VFs. Prevalence of osteoporosis was 32.9% measured by BMD and 40.8% using NOF/IOF clinical diagnosis criteria. Conclusion VFs are prevalent among Chinese postmenopausal women who were >= 50 years and community-dwelled. Osteoporosis prevalence is remarkable when fragile fractures were part of clinical diagnosis."

基金机构："Merck Sharp & Dohme China, Shanghai, China"

基金资助正文："This work was supported by Merck Sharp & Dohme China, Shanghai, China."