Multifaceted Influence of Histone Deacetylases on DNA Damage Repair: Implications for Hepatocellular Carcinoma

作者全名："Du, Gan; Yang, Ruizhe; Qiu, Jianguo; Xia, Jie"

作者地址："[Du, Gan; Yang, Ruizhe; Xia, Jie] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China; [Du, Gan; Yang, Ruizhe] Chongqing Med Univ, Clin Coll 1, Chongqing, Peoples R China; [Qiu, Jianguo] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing, Peoples R China; [Xia, Jie] Minist Educ, Key Lab Mol Biol Infect Dis, 1 Yi Xue Yuan Rd, Chongqing 400016, Peoples R China; [Qiu, Jianguo] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 You Yi Rd, Chongqing 400016, Peoples R China"

通信作者："Xia, J (通讯作者)，Minist Educ, Key Lab Mol Biol Infect Dis, 1 Yi Xue Yuan Rd, Chongqing 400016, Peoples R China.; Qiu, JG (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 You Yi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY

ESI学科分类：　

WOS号：WOS:000862357700001

JCR分区：Q2

影响因子：3.6

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Histone deacetylases; DNA repair; Hepatocellular carcinoma

摘要："Hepatocellular carcinoma (HCC) is one of the most common-ly diagnosed cancers and a leading cause of cancer-related mortality worldwide, but its pathogenesis remains largely unknown. Nevertheless, genomic instability has been rec-ognized as one of the facilitating characteristics of cancer hallmarks that expedites the acquisition of genetic diversity. Genomic instability is associated with a greater tendency to accumulate DNA damage and tumor-specific DNA repair defects, which gives rise to gene mutations and chromo-somal damage and causes oncogenic transformation and tu-mor progression. Histone deacetylases (HDACs) have been shown to impair a variety of cellular processes of genome stability, including the regulation of DNA damage and repair, reactive oxygen species generation and elimination, and pro-gression to mitosis. In this review, we provide an overview of the role of HDAC in the different aspects of DNA repair and genome instability in HCC as well as the current progress on the development of HDAC-specific inhibitors as new cancer therapies."

基金机构：Science and Technology Research Program of Chongqing Education Com-mission; Natural Science Foundation Project of Chongqing; [KJQN202100424]; [cstc2018jcyjAX0825]

基金资助正文：Acknowledgments Funding This work was supported by grants from the Science and Technology Research Program of Chongqing Education Com-mission (no. KJQN202100424) and the Natural Science Foundation Project of Chongqing (no. cstc2018jcyjAX0825) .