Reliability and validity of prognostic indicators for Guillain-Barre syndrome in children

作者全名：Huang Qinrong; Chen Yuxia; Liu Ling; Luo Huayu; Xu Lei; Li Xiaoli; Xiao Nong

作者地址："[Huang Qinrong; Chen Yuxia; Liu Ling; Luo Huayu; Li Xiaoli; Xiao Nong] Chongqing Med Univ, Childrens Hosp, Dept Rehabil,Chongqing Key Lab Pediat,Key Lab Chi, Minist Educ,Natl Clin Res Ctr Child Hlth & Disord, 136,2nd Zhongshan Rd, Chongqing, Peoples R China; [Xu Lei] Fudan Univ, Childrens Hosp, Dept Rehabil, Shanghai, Peoples R China"

通信作者："Xiao, N (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Rehabil,Chongqing Key Lab Pediat,Key Lab Chi, Minist Educ,Natl Clin Res Ctr Child Hlth & Disord, 136,2nd Zhongshan Rd, Chongqing, Peoples R China."

来源：DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000862918800001

JCR分区：Q1

影响因子：3.8

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

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摘要："Aim To explore the clinical characteristics and prognostic predictors of Guillain-Barre syndrome (GBS) in Chinese paediatric patients. Method The clinical features of children with GBS hospitalized in the Children's Hospital of Chongqing Medical University were summarized retrospectively. The correlation between the Erasmus GBS Outcome Score (EGOS)/modified Erasmus GBS Outcome Score (mEGOS), GBS disability score (GDS)/modified Rankin Scale (MRS), Erasmus GBS Respiratory Insufficiency Score (EGRIS), and mechanical ventilation were evaluated. Results One hundred forty-two patients (86 males, 56 females; median 62.50 months [interquartile range 41.00-97.50]) with classic GBS were enrolled in the study. In the present GBS cohort, 134 (94.37%) patients could walk independently (GDS <= 2) and 121 (85.21%) could manage without assistance (MRS <= 2) at 6 months. Eighteen (12.68%) patients with GBS required mechanical ventilation. The performance of mEGOS on admission, mEGOS on day 7, and EGOS-predicted GDS outcome at 4 weeks, 3 months, and 6 months in the paediatric patients with GBS admitted within 2 weeks of disease onset and that of the MRS outcome were evaluated. The EGRIS in individuals who required mechanical ventilation was significantly higher than in patients without mechanical ventilation (median = 6 vs median = 3, p < 0.001). Interpretation In Chinese paediatric patients with GBS who were admitted 2 weeks after disease onset, the mEGOS and EGOS are validated indicators for the prediction of clinical outcomes 6 months after onset. EGRIS is helpful in predicting the implementation of mechanical ventilation in the acute phase."

基金机构：Chongqing Medical University

基金资助正文：Chongqing Medical University