Polarized Autologous Macrophages (PAM) Can Be a Tumor Vaccine

作者全名："Wang, Dongqing; Chen, Heying; Hu, Yi"

作者地址："[Wang, Dongqing; Chen, Heying] Chongqing Med Univ, Coll Lab Med, MOE Key Lab Lab Med Diagnost, Chongqing 400016, Peoples R China; [Hu, Yi] Univ Chinese Acad Sci UCAS, Inst High Energy Phys, Chinese Acad Sci CAS, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China"

通信作者："Wang, DQ (通讯作者)，Chongqing Med Univ, Coll Lab Med, MOE Key Lab Lab Med Diagnost, Chongqing 400016, Peoples R China.; Hu, Y (通讯作者)，Univ Chinese Acad Sci UCAS, Inst High Energy Phys, Chinese Acad Sci CAS, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China."

来源：ONCOLOGIE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000863681900005

JCR分区：Q4

影响因子：0.9

年份：2022

卷号：24

期号：3

开始页：441

结束页：449

文献类型：Article

关键词：Polarized autologous macrophages; immunotherapy; solid tumors; vaccine; hydrogel

摘要："Immunotherapy is currently recognized as one of the most promising anticancer strategies. In the tumor micro -environment, tumor-associated macrophages are mainly M2-type macrophages with tumor-promoting effects. Therefore, the reprogramming of tumor-associated macrophages from M2 to M1 type is a potential strategy for cancer therapy. We have previously shown the anticancer effects of implantable allogeneic M1 macrophages in mice. Here, we further engineered autologous mouse bone marrow cells into M1 macrophages and then embedded them into a sodium alginate gel to prepare an implantable immunotherapeutic agent (M1@Gel). We demonstrate that M1@Gel repolarizes M2 macrophages to M1 type and activates the immune responses in mice. As a result, M1@Gel can potently inhibit the tumor recurrence in mice after the surgical tumor removal. These results suggest that the implantation of autologous M1 macrophages might be a promising strategy for pre-venting postoperative tumor recurrence. We envisage that the employment of polarized autologous macrophages as a tumor vaccine might be translated into clinic."

基金机构：Beijing Natural Science Foundation; [7212212]

基金资助正文：Funding Statement: This work is financially supported by Beijing Natural Science Foundation (No. 7212212) .