Cost-Effectiveness of Adding Empagliflozin to Standard Treatment for Heart Failure with Preserved Ejection Fraction Patients in China

作者全名："Lou, Yake; Hu, Tianyang; Huang, Jing"

作者地址："[Lou, Yake; Huang, Jing] Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Hu, Tianyang] Chongqing Med Univ, Affiliated Hosp 2, Precis Med Ctr, Chongqing, Peoples R China"

通信作者："Huang, J (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Cardiol, 76 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000864958900001

JCR分区：Q3

影响因子：3

年份：2022

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期号：　

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结束页：　

文献类型：Article; Early Access

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摘要："Objectives Heart failure is a worldwide health problem and is the leading cause of hospitalization in older patients. Heart failure with preserved ejection fraction (HFpEF) accounts for about 38% of heart failure cases. The latest EMPEROR-Preserved study shows that empagliflozin can reduce the risk of hospitalization in HFpEF, but whether empagliflozin is cost-effective in HFpEF in a Chinese setting remained uninvestigated. Methods A simulation of lifetime horizon for a 72-year-old HFpEF patient was conducted using a Markov model. The primary outcome was incremental cost-effectiveness ratio (ICER), expressed as incremental costs per quality-adjusted life-year (QALY). Three times the per capita GDP of China was set as the willingness-to-pay (WTP) threshold. Empagliflozin was considered cost-effective if the ICER was below the WTP threshold, otherwise it would be regarded as not cost-effective. One-way sensitivity and probabilistic sensitivity analysis (PSA) were used to assess uncertainty. Results After a simulation of lifetime horizon, a 72-year-old HFpEF patient is expected to have an expected QALY of 4.80 in the empagliflozin group, and 4.67 QALY with standard treatment. The costs of empagliflozin and standard treatment are 34,987 (US$5423) and 27,027 (US$4189) Chinese Yuan (CNY), respectively, with an ICER of 63,746 (US$9881)/QALY, lower than the WTP threshold. One-way sensitivity and PSA show that our results are robust. Conclusion In Chinese HFpEF patients, adding empagliflozin to standard treatment is cost-effective, but studies based on real-world data are needed."

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