The interleukin-6 family in tissues is closely related to the clinical outcomes of oral lichen planus

作者全名："Qing, Maofeng; Zhou, Yu; Peng, Jiakuan; Shang, Qianhui; Deng, Jiaxin; Zeng, Xin; Xu, Hao; Chen, Qianming"

作者地址："[Qing, Maofeng; Zhou, Yu; Peng, Jiakuan; Shang, Qianhui; Deng, Jiaxin; Zeng, Xin; Xu, Hao; Chen, Qianming] Sichuan Univ, West China Hosp Stomatol, Chinese Acad Med Sci,Natl Clin Res Ctr Oral Dis, Res Unit Oral Carcinogenesis & Management,State K, Chengdu, Peoples R China; [Qing, Maofeng] Chongqing Med Univ, Affiliated Hosp 2, Dept Stomatol, Chongqing, Peoples R China"

通信作者："Xu, H; Chen, QM (通讯作者)，Sichuan Univ, West China Hosp Stomatol, Chinese Acad Med Sci,Natl Clin Res Ctr Oral Dis, Res Unit Oral Carcinogenesis & Management,State K, Chengdu, Peoples R China."

来源：JOURNAL OF ORAL PATHOLOGY & MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000865407800001

JCR分区：Q2

影响因子：3.3

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：clinical outcomes; erosive; IL-6; oral lichen planus; transcriptome

摘要："Objective We attempted to investigate the role of interleukin-6 (IL-6) family expression in local tissues as it relates to presentations and outcomes in oral lichen planus (OLP), which is a common chronic inflammatory oral disease. Materials and Methods A clinical follow-up cohort of OLP patients was established, and a biological sample library was constructed with categorization into erosive type (EOLP) and nonerosive type (NEOLP). Transcriptome sequencing of the lesions was then performed. A multiple regression model was used to explore the differences in IL-6 family expression among patients with different clinical types and clinical outcomes. Results OLP tissue transcriptome sequencing showed that IL-6 family expression in EOLP increased significantly. It was also found that IL-6 family factors in the OLP recurrent erosion group were significantly increased compared to the persistent nonerosion group. Based on the multiple regression analysis of the OLP clinical cohort, it was found that the increased expression of the IL-6 family was closely related to the clinical types and clinical outcomes of OLP. Conclusion The high expression of the IL-6 family is closely related to the erosion of local mucosa and poor prognosis of OLP patients. IL-6-related factors may be used as therapeutic targets for OLP patients."

基金机构："National Natural Science Foundation of China [81730030, 81771081]"

基金资助正文：This study was supported by the National Natural Science Foundation of China (grant numbers 81730030 and 81771081).