Brain age gap in neuromyelitis optica spectrum disorders and multiple sclerosis

作者全名："Wei, Ren; Xu, Xiaolu; Duan, Yunyun; Zhang, Ningnannan; Sun, Jie; Li, Haiqing; Li, Yuxin; Li, Yongmei; Zeng, Chun; Han, Xuemei; Zhou, Fuqing; Huang, Muhua; Li, Runzhi; Zhuo, Zhizheng; Barkhof, Frederik; Cole, James H.; Liu, Yaou"

作者地址："[Wei, Ren; Xu, Xiaolu; Duan, Yunyun; Zhuo, Zhizheng; Liu, Yaou] Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China; [Zhang, Ningnannan; Sun, Jie] Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China; [Zhang, Ningnannan; Sun, Jie] Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China; [Li, Haiqing; Li, Yuxin] Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai, Peoples R China; [Li, Yongmei; Zeng, Chun] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Han, Xuemei] Jilin Univ, Dept Neurol, China Japan Union Hosp, Changchun, Peoples R China; [Zhou, Fuqing; Huang, Muhua] Nanchang Univ, Dept Radiol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China; [Li, Runzhi] Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [Barkhof, Frederik] VU Univ Med Ctr Amsterdam, Dept Radiol & Nucl Med, Neurosci Campus Amsterdam, Amsterdam, Netherlands; [Barkhof, Frederik; Cole, James H.] UCL, Ctr Med Image Comp, Dept Comp Sci, London, England; [Cole, James H.] UCL, Dementia Res Ctr, Queen Sq Inst Neurol, London, England"

通信作者："Liu, YO (通讯作者)，Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China."

来源：JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000866157100001

JCR分区：Q1

影响因子：11.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：neuroimmunology; MRI; multiple sclerosis; neuroradiology

摘要："Objective To evaluate the clinical significance of deep learning-derived brain age prediction in neuromyelitis optica spectrum disorder (NMOSD) relative to relapsing-remitting multiple sclerosis (RRMS). Methods This cohort study used data retrospectively collected from 6 tertiary neurological centres in China between 2009 and 2018. In total, 199 patients with NMOSD and 200 patients with RRMS were studied alongside 269 healthy controls. Clinical follow-up was available in 85 patients with NMOSD and 124 patients with RRMS (mean duration NMOSD=5.8 +/- 1.9 (1.9-9.9) years, RRMS=5.2 +/- 1.7 (1.5-9.2) years). Deep learning was used to learn 'brain age' from MRI scans in the healthy controls and estimate the brain age gap (BAG) in patients. Results A significantly higher BAG was found in the NMOSD (5.4 +/- 8.2 years) and RRMS (13.0 +/- 14.7 years) groups compared with healthy controls. A higher baseline disability score and advanced brain volume loss were associated with increased BAG in both patient groups. A longer disease duration was associated with increased BAG in RRMS. BAG significantly predicted Expanded Disability Status Scale worsening in patients with NMOSD and RRMS. Conclusions There is a clear BAG in NMOSD, although smaller than in RRMS. The BAG is a clinically relevant MRI marker in NMOSD and RRMS."

基金机构：National Natural Science Foundation of China [81870958]; Beijing Municipal Natural Science Foundation for Distinguished Young Scholars [JQ20035]; Beijing Young Scholarship; Capital's Funds for Health Improvement and Research [CFH2022-1-2042]; NIHR Biomedical Research Centre at UCLH

基金资助正文："This work was supported by the National Natural Science Foundation of China (No. 81870958), the Beijing Municipal Natural Science Foundation for Distinguished Young Scholars (No. JQ20035), Beijing Young Scholarship and the Capital's Funds for Health Improvement and Research (CFH2022-1-2042). FB is supported by the NIHR Biomedical Research Centre at UCLH."