Therapy for Psychiatric Comorbidities in Patients with Episodic Cluster Headache: A Prospective Multicenter

作者全名："Liu, Qinlin; Zhang, Yixin; Hu, Chuan; Yuan, Dongli; Wang, Kuiyun; Fan, Wen; Pan, Feibao; Li, Qin; Wang, Yunfeng; Tan, Ge"

作者地址："[Liu, Qinlin; Zhang, Yixin; Wang, Yunfeng; Tan, Ge] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China; [Hu, Chuan] Peoples Hosp Bishan Dist, Dept Neurol, Bishan, Peoples R China; [Yuan, Dongli] Chongqing Med Univ, Dept Intelligent Med Syst, Chongqing, Peoples R China; [Wang, Kuiyun] Jintang First Peoples Hosp, Dept Neurol, Sichuan, Peoples R China; [Fan, Wen] Guizhou Prov Peoples Hosp, Dept Neurol, Guiyang, Peoples R China; [Pan, Feibao] Suining Cent Hosp, Dept Neurol, Suining, Peoples R China; [Li, Qin] Chongqing Gen Hosp, Dept Neurol, Chongqing, Peoples R China; [Tan, Ge] Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China"

通信作者："Tan, G (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing, Peoples R China."

来源：JOURNAL OF PAIN RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000874533400001

JCR分区：Q3

影响因子：2.7

年份：2022

卷号：15

期号：　

开始页：3245

结束页：3254

文献类型：Article

关键词：cluster headache; depression; anxiety; sleep disturbance; psychiatric comorbidities

摘要："Purpose: To explore changes of depression, anxiety and sleep disturbance in patients with episodic cluster headache inside and outside the attack period and assess the therapy to improve the treatment.Patients and Methods: We prospectively recruited 396 patients from 11 specialized headache outpatients and analyzed their headache characteristics, Hospital Anxiety Depression Scale scores, Pittsburgh sleep quality index scores, and the usage of psychiatric medications during as well as 1 month after the attack period.Results: A total of 220 patients completed the follow-up, 52.73% of whom had anxiety, 47.27% had depression and 49.09% had sleep disturbance inside the attack period. At follow-up, the percentage of these patients significantly decreased to 16.36%, 21.82% and 14.55% in the remission period, respectively (p < 0.05). Antidepressants and mood stabilizers were prescribed to 58.18% of the patients. However, both of the changes of Hospital Anxiety Depression Scale scores after the end of the attack period for anxiety (3.52 +2.91 vs 3.32+3.09, p =0.61) and depression (3.41+3.33 vs 2.90+3.58, P =0.28) were comparable in patients with and without taking these medications. Nocturnal onset of headache was positively correlated with Pittsburgh score (OR=8.71), anxiety (OR=2.33) and depression scores (OR=3.56) (p < 0.05).Conclusion: Depression, anxiety and sleep disturbance were significantly alleviated after the attack period. However, psychiatric medications showed limited effect on depression and anxiety. Additionally, the nocturnal attack may cause anxiety and depression in cluster headache."

基金机构：Chongqing Medical Scientific Research Project of Chongqing Health Commission and Science and Technology Bureau; Scientific Research Project of Chongqing Yuzhong Science and Technology Commission; [2020MSXM096]; [20180154]

基金资助正文：Funding This study was supported by Chongqing Medical Scientific Research Project of Chongqing Health Commission and Science and Technology Bureau (2020MSXM096) and the Scientific Research Project of Chongqing Yuzhong Science and Technology Commission (20180154) .