"Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role"

作者全名："Zhang, Hao; Wang, Ruixuan; Wang, Zeyu; Wu, Wantao; Zhang, Nan; Zhang, Longbo; Hu, Jason; Luo, Peng; Zhang, Jian; Liu, Zaoqu; Feng, Songshan; Peng, Yun; Liu, Zhengzheng; Cheng, Quan"

作者地址："[Zhang, Hao; Wang, Zeyu; Zhang, Nan; Zhang, Longbo; Feng, Songshan; Cheng, Quan] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China; [Wang, Ruixuan; Wu, Wantao; Liu, Zhengzheng] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha, Peoples R China; [Zhang, Nan] Harbin Med Univ, Coll Bioinformat Sci & Technol, One Lab 3, Harbin, Peoples R China; [Zhang, Longbo] Yale Univ, Dept Neurosurg, Dept Cellular & Mol Physiol, Sch Med, New Haven, CT USA; [Hu, Jason] Yale Univ, Dept Neonatol, Sch Med, New Haven, CT USA; [Luo, Peng; Zhang, Jian] Southern Med Univ, Zhujiang Hosp, Dept Oncol, Guangzhou, Peoples R China; [Liu, Zaoqu] Zhengzhou Univ, Affiliated Hosp 1, Dept Intervent Radiol, Zhengzhou, Peoples R China; [Peng, Yun] Cent South Univ, Xiangya Hosp, Dept Geriatr, Changsha, Peoples R China; [Zhang, Hao; Wang, Ruixuan; Wang, Zeyu; Wu, Wantao; Zhang, Longbo; Feng, Songshan; Peng, Yun; Liu, Zhengzheng; Cheng, Quan] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China; [Zhang, Hao] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurosurg, Chongqing, Peoples R China; [Liu, Zhengzheng] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China; [Cheng, Quan] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China"

通信作者："Liu, ZZ (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China.; Cheng, Q (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China."

来源：BIOMEDICINE & PHARMACOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000874584000005

JCR分区：Q1

影响因子：7.5

年份：2022

卷号：156

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：PTX3; Innate immunity; Tissue remodeling; Oncogenesis; COVID-19

摘要："Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase protein consisting of a C -terminal pentraxin domain and a unique N-terminal domain. PTX3 was initially isolated from human umbilical vein endothelial cells and human FS-4 fibroblasts. It was subsequently found to be also produced by synovio-cytes, chondrocytes, osteoblasts, smooth muscle cells, myeloid dendritic cells, epithelial cells, and tumor cells. Various modulatory factors, such as miRNAs, cytokines, drugs, and hypoxic conditions, could regulate the expression level of PTX3. PTX3 is essential in regulating innate immunity, inflammation, angiogenesis, and tissue remodeling. Besides, PTX3 may play dual (pro-tumor and anti-tumor) roles in oncogenesis. PTX3 is involved in the occurrence and development of many non-cancerous diseases, including COVID-19, and might be a potential biomarker indicating the prognosis, activity,and severity of diseases. In this review, we summarize and discuss the potential roles of PTX3 in the oncogenesis and pathogenesis of non-cancerous diseases and potential targeted therapies based on PTX3."

基金机构：National Natural Science Foundation of China; Hunan Provincial Natural Science Foundation of China; Hunan Provincial Health Committee Foundation of China; Xiangya Hospital Central South University post- doctoral foundation; [81803582]; [82073893]; [81703622]; [82102848]; [2022JJ20095]; [2020JJ4896]; [202204044869]

基金资助正文："This work was supported by the National Natural Science Foundation of China (NO.81803582, 82073893, 81703622 and 82102848) . Hunan Provincial Natural Science Foundation of China (NO.2022JJ20095, 2020JJ4896) . Hunan Provincial Health Committee Foundation of China (NO.202204044869) . Xiangya Hospital Central South University post- doctoral foundation."