Serological Evidence of Hepatitis E Virus (HEV) Infection Among Ruminant Farmworkers: A Retrospective Study from Malaysia

作者全名："Wong, Li Ping; Tay, Sun Tee; Chua, Kek Heng; Goh, Xiang Ting; Alias, Haridah; Zheng, Zizheng; Zhao, Qinjian; Wu, Ting; Xia, Ningshao; Hu, Zhijian; Lin, Yulan"

作者地址："[Wong, Li Ping; Alias, Haridah] Univ Malaya, Fac Med, Ctr Epidemiol & Evidence Based Practice, Dept Social & Prevent Med, Kuala Lumpur 50603, Malaysia; [Wong, Li Ping; Hu, Zhijian; Lin, Yulan] Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Fuzhou 350122, Fujian, Peoples R China; [Tay, Sun Tee] Univ Malaya, Fac Med, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia; [Chua, Kek Heng; Goh, Xiang Ting] Univ Malaya, Fac Med, Dept Biomed Sci, Kuala Lumpur 50603, Malaysia; [Zheng, Zizheng; Wu, Ting; Xia, Ningshao] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China; [Zhao, Qinjian] Chongqing Med Univ, Coll Pharm, Chongqing, Peoples R China; [Xia, Ningshao] Xiamen Univ, Res Unit Frontier Technol Struct Vaccinol, Chinese Acad Med Sci, Xiamen 361102, Peoples R China; [Lin, Yulan] Fujian Med Univ, Sch Publ Hlth, Fuzhou 350122, Fujian, Peoples R China; [Wong, Li Ping] Univ Malaya, Fac Med, Kuala Lumpur, Malaysia"

通信作者："Lin, YL (通讯作者)，Fujian Med Univ, Sch Publ Hlth, Fuzhou 350122, Fujian, Peoples R China.; Wong, LP (通讯作者)，Univ Malaya, Fac Med, Kuala Lumpur, Malaysia."

来源：INFECTION AND DRUG RESISTANCE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000874925100001

JCR分区：Q2

影响因子：3.9

年份：2022

卷号：15

期号：　

开始页：5533

结束页：5541

文献类型：Article

关键词：HEV; farmworkers; seroprevalence; antibody

摘要："Background: As scant data are available about Hepatitis E virus (HEV) infection in Malaysia, this study aimed to determine the seroprevalence of HEV amongst ruminant farmworkers in Malaysia. Methods: A total of 87 farmworkers provided serum samples, which were collected from eight farms. All serum samples were tested for anti-HEV IgG and anti-HEV IgM by an enzyme-linked immunosorbent assay (ELISA) using the Wantai HEV-IgG and HEV-IgMResults: Farmworkers from six cattle farms, one sheep farm and one goat farm were investigated in this study. Only one farm practices zero-grazing, with the rest using rotational grazing. Of the 87 farmworkers, males comprised 83.9%, and almost half (47.1%) were aged 20-35 years old. By ethnic group, the vast majority were Malay. Most of the farmworkers have good hygiene practices; washing or changing their clothes and showering after dealing with farm animals were common. None of the farmworker serum samples had anti-HEV IgM and IgG detected (95% confidence interval (CI): 0, 0.0415).Conclusion: The finding suggests that the farmworkers had no previous exposure to Hepatitis E, and were not at risk of occupational exposure to HEV infection. Our findings suggest that a zero seroprevalence of HEV infection among ruminant farmworkers in the Muslim majority country. Good farm management, hygiene practices and the absence of contact with swine-related contamination might have contributed to the no or minimal zoonotic risks of HEV amongst farmworkers surveyed in this study."

基金机构："Newton -Medical Research Council [IF077-2019]; National Natural Science Foundation of China [81871247, 82071783]; Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences (CAMS) , Innovation Fund for Medical Sciences [2019RU022]"

基金资助正文："This work is supported by1) Newton -Medical Research Council grant (IF077-2019) ,2) National Natural Science Foundation of China (No. 81871247, No.82071783) , and3) Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences (CAMS) ,Innovation Fund for Medical Sciences (No. 2019RU022) .The funders were not involved in study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; nor in the decision to submit the manuscript for publication."