A well-matched marriage of immunotherapy and radiofrequency ablation to reduce the relapse and progression of hepatocellular carcinoma

作者全名："Liao, Rui; Song, Peipei; Duan, Yuxin; Ye, Wentao; Yin, Kunli; Kang, Meiqing; Yu, Yanxi; Yang, Jian; Tang, Wei"

作者地址："[Liao, Rui; Duan, Yuxin; Ye, Wentao; Yin, Kunli; Kang, Meiqing; Yu, Yanxi; Yang, Jian] Chongqing Med Univ, Dept Hepatobiliary Surg, Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Liao, Rui; Song, Peipei; Tang, Wei] Natl Ctr Global Hlth & Med, Tokyo, Japan; [Tang, Wei] Univ Tokyo Hosp, Dept Surg, Hepatobiliary Pancreat Surg Div, Tokyo, Japan"

通信作者："Liao, R (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：BIOSCIENCE TRENDS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000874979100001

JCR分区：Q1

影响因子：5.5

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：immunotherapy; radiofrequency ablation; hepatocellular carcinoma; recurrence; metastasis

摘要："Hepatocellular carcinoma (HCC) remains a health challenge with increasing incidence worldwide. Radiofrequency ablation (RFA) is a potentially curative option for patients with early-stage HCC. However, the high rate of tumor recurrence limits long-term survival when the tumors are larger than 2 cm and undergoing insufficient RFA (iRFA). Notably, in situ tumor necrosis due to thermal ablation is assumed to be a source of antigens that induce antitumor immunity. Therefore, mounting studies and trials have attempted to provide a rational and effective therapeutic strategy combining RFA and immunotherapy to treat HCC. Nowadays, many controversies and challenges with this combined therapeutic strategy remain to be resolved, such as the indications for adjuvant immunotherapy along with RFA in early HCC, the sequence of the two treatments in advanced HCC, and the optimal timing of immunotherapy before or after RFA. In addition, individualized treatment strategies need to be perfected for patients with HCC."

基金机构：Sino-Japanese Sasagawa Medical Scholarship Program; Joint Science and Health Research Project of the City of Chongqing Municipality [2020GDRC013]; Chongqing Medical University Program for Young Innovators in Future Medicine [W0087]

基金资助正文："This work was supported by a grant from the Sino-Japanese Sasagawa Medical Scholarship Program, the Joint Science and Health Research Project of the City of Chongqing Municipality (2020GDRC013) , and the Chongqing Medical University Program for Young Innovators in Future Medicine (W0087) ."