The Efficacy of Twin-Block Appliances for the Treatment of Obstructive Sleep Apnea in Children: A Systematic Review and Meta-Analysis

作者全名："Duan, Jun; Xia, Wanyuan; Yang, Kai; Li, Xuelei; Zhang, Feng; Xu, Jie; Jiang, Ying; Liang, Jia; Li, Bing"

作者地址："[Duan, Jun] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Stomatol,Chongqing Key Lab Pediat, Minist Educ,Key Lab Child Dev & Disorders,Childre, Chongqing 400014, Peoples R China; [Xia, Wanyuan] Chongqing Three Gorges Med Coll, Dept Publ Hlth & Management, Chongqing 404120, Peoples R China; [Yang, Kai; Li, Bing] Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Li, Xuelei; Zhang, Feng; Xu, Jie; Jiang, Ying; Liang, Jia] Chongqing Med Univ, Dept Otolaryngol, Childrens Hosp, Chongqing 400014, Peoples R China"

通信作者："Li, B (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：BIOMED RESEARCH INTERNATIONAL

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000876072000002

JCR分区：Q3

影响因子：3.246

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Objective. To evaluate the efficacy of twin-block appliance in the treatment of children with obstructive sleep apnea (OSA). Methods. Two independent reviewers conducted a systematic review of seven databases from database establishment until October 16, 2021. There were no language restrictions. The outcomes were changes in apnea-hypopnea index (AHI), oxyhemoglobin desaturation index (ODI), and lowest arterial oxygen saturation (lowest SaO2). National Institute for Health and Clinical Excellence (NICE) tool was used to assess the quality of the studies included. Results. A total of 207 articles were screened for relevance, and 6 of them met the inclusion criteria for our meta-analysis. Four of the studies were case series, 1 was nonrandomized control trial, and 1 was a randomized crossover clinical trial. After twin-block therapy, there was a significant decrease in AHI (4.35 events/hour, 95% CI: 4.04, 4.66, p <= 0:001). The lowest SaO(2) significantly increased by 9.17% (95% CI: 12.05, 6.28, p <= 0:001). Sensitivity analysis by excluding studies one by one showed stable and favorable results in lowest SaO(2) and AHI. Conclusions. Results from the meta-analysis showed that the use of twin-block appliance significantly decreased AHI and significantly increased lowest SaO(2). Hence, twin-block appliance therapy may be an effective method for the treatment of pediatric OSA. Further large sample size randomized controlled trials are needed to assess this treatment efficacy in children with obstructive sleep apnea."

基金机构："General Program of Chongqing Science and Technology Commission Natural Science Foundation [cstc2016shmszx130035, 2019XZYB21]"

基金资助正文：Our research was supported by the General Program of Chongqing Science and Technology Commission Natural Science Foundation: cstc2016shmszx130035 and General Program of Chongqing Three Gorges Medical College Natural Science in 2019: 2019XZYB21.