Effect of AMPK Subunit Alpha 2 Polymorphisms on Postherpetic Pain Susceptibility in Southwestern Han Chinese

作者全名："Mei, Yang; Mu, Yang; Wang, Win; Tan, Bo-Tao; Chen, Yao-Hua; Li, Yu-Ping; Zhu, Dan; Li, Wei; Cui, Jian; Yu, Le-Hua"

作者地址："[Mei, Yang; Tan, Bo-Tao; Yu, Le-Hua] Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Chongqing, Peoples R China; [Mei, Yang; Wang, Win; Li, Wei] Chongqing Hosp Tradit Chinese Med, Dept Pain Med, Chongqing, Peoples R China; [Mu, Yang] Chongqing Univ Fuling Hosp, Dept Rehabil Med, Chongqing, Peoples R China; [Chen, Yao-Hua; Li, Yu-Ping; Zhu, Dan; Cui, Jian] Army Med Univ, Southwest Hosp, Dept Pain Med, Chongqing, Peoples R China"

通信作者："Yu, LH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil Med, Chongqing, Peoples R China.; Cui, J (通讯作者)，Army Med Univ, Southwest Hosp, Dept Pain Med, Chongqing, Peoples R China."

来源：JOURNAL OF PAIN RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000876736900001

JCR分区：Q3

影响因子：2.7

年份：2022

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：population; AMPK; PRKAA2; polymorphism; postherpetic neuralgia

摘要："Introduction: Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) can influence energy metabolism. Energy metabolism imbalance is closely associated with the occurrence of neuropathic pain (NeP). Rs10789038 and rs2796498 are genetic polymorphisms of PRKAA2, the gene encoding AMPK, which is closely related to energy metabolism imbalance. This study aimed to explore the relationship between PRKAA2 and postherpetic neuralgia (PHN) in the southwestern Chinese Han population.Methods: This study enrolled 132 PHN patients and 118 healthy subjects. The rs10789038 and rs2796498 PRKAA2 genotypes were identified in all participants. The association between these single nucleotide polymorphisms and PHN susceptibility was evaluated in the dominant and recessive models. Haplotype analysis of patients with PHN and healthy controls was performed.Results: The PHN patients were older than the healthy subjects (P < 0.05); however, the other clinical characteristics between two groups were not significantly different (all P >0.05). Genotypes and allele frequencies differed significantly between PHN patients and healthy subjects in the rs10789038 polymorphism (P < 0.05), but not in rs2796498 (P > 0.05). In addition, the GG haplotype of rs10789038-rs2796498 correlated negatively with PHN occurrence in haplotype analysis (P < 0.05).Conclusion: PHN occurrence may be related to the PRKAA2 rs10789038 A>G genetic polymorphism in the southwestern Chinese"

基金机构：National Natural Science Foundation of China [81870883]; 2021 "Xinglin Scholar" Hospital Special Project of Chengdu University of Traditional Chinese Medicine [YYZX050]; Chongqing Scientific Research Institution Performance Incentive and Guidance Special Project [cstc2021jxjl130022]; Natural Science Foundation of Chongqing [cstc2018jcyjAX0180]

基金资助正文："This research has been granted by the National Natural Science Foundation of China (81870883), 2021 ""Xinglin Scholar"" Hospital Special Project of Chengdu University of Traditional Chinese Medicine (YYZX050), Chongqing Scientific Research Institution Performance Incentive and Guidance Special Project (cstc2021jxjl130022) and Natural Science Foundation of Chongqing (cstc2018jcyjAX0180)."