Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases

作者全名："Yin, Kun -Li; Li, Ming; Song, Pei-Pei; Duan, Yu-Xin; Ye, Wen-Tao; Tang, Wei; Kokudo, Norihiro; Gao, Qiang; Liao, Rui"

作者地址："[Yin, Kun -Li; Li, Ming; Duan, Yu-Xin; Ye, Wen-Tao; Liao, Rui] Chongqing Med Univ, Dept Hepatobiliary Surg, Hosp 1, Chongqing, Peoples R China; [Song, Pei-Pei; Tang, Wei; Kokudo, Norihiro] Natl Ctr Global Hlth & Med, Tokyo, Japan; [Gao, Qiang] Fudan Univ, Inst Biomed Sci, Key Lab Med Epigenet & Metab, Shanghai, Peoples R China; [Gao, Qiang] Fudan Univ, Dept Liver Surg & Transplantat, Shanghai, Peoples R China; [Gao, Qiang] Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Key Lab Carcinogenesis & Canc Invas,Minist Educ, Shanghai, Peoples R China; [Gao, Qiang] Fudan Univ, State Key Lab Genet Engn, Shanghai, Peoples R China; [Gao, Qiang] Fudan Univ, Liver Canc Inst, Inst Biomed Sci, Key Lab Carcinogenesis & Canc Invas,Minist Educ, 180 Fenglin Rd, Shanghai 200032, Peoples R China; [Gao, Qiang] Fudan Univ, Dept Liver Surg & Transplantat, 180 Fenglin Rd, Shanghai 200032, Peoples R China; [Liao, Rui] Chongqing Med Univ, Hosp 1, Dept Hepatobiliary Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Liao, R (通讯作者)，Chongqing Med Univ, Dept Hepatobiliary Surg, Hosp 1, Chongqing, Peoples R China.; Gao, Q (通讯作者)，Fudan Univ, State Key Lab Genet Engn, Shanghai, Peoples R China.; Gao, Q (通讯作者)，Fudan Univ, Liver Canc Inst, Inst Biomed Sci, Key Lab Carcinogenesis & Canc Invas,Minist Educ, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Gao, Q (通讯作者)，Fudan Univ, Dept Liver Surg & Transplantat, 180 Fenglin Rd, Shanghai 200032, Peoples R China.; Liao, R (通讯作者)，Chongqing Med Univ, Hosp 1, Dept Hepatobiliary Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY

ESI学科分类：　

WOS号：WOS:000877120100001

JCR分区：Q2

影响因子：3.6

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：Myofibroblast; Extracellularvesicle; Hepatic fibrosis; Cancer; Meta-bolic reprogramming; Biomarker

摘要："Hepatic stellate cells (HSCs) play an essential role in vari-ous liver diseases, and exosomes are critical mediators of intercellular communication in local and distant microenvi-ronments. Cellular crosstalk between HSCs and surround-ing multiple tissue-resident cells promotes or inhibits the activation of HSCs. Substantial evidence has revealed that HSC-derived exosomes are involved in the occurrence and development of liver diseases through the regulation of retinoid metabolism, lipid metabolism, glucose metabolism, protein metabolism, and mitochondrial metabolism. HSC-derived exosomes are underpinned by vehicle molecules, such as mRNAs and microRNAs, that function in, and sig-nificantly affect, the processes of various liver diseases, such as acute liver injury, alcoholic liver disease, nonalco-holic fatty liver disease, viral hepatitis, fibrosis, and cancer. As such, numerous exosomes derived from HSCs or HSC-associated exosomes have attracted attention because of their biological roles and translational applications as poten-tial targets for therapeutic targets. Herein, we review the pathophysiological and metabolic processes associated with HSC-derived exosomes, their roles in various liver diseases and their potential clinical application."

基金机构："Japanese China Sasakawa Medical Fellowship, Science and Health Joint Research Project of Chongqing Municipality [2020GDRC013]; Pro-gram for Youth Innovation in Future Medicine, Chongqing Medical University [W0087]"

基金资助正文："This study was supported by Japanese China Sasakawa Medical Fellowship, Science and Health Joint Research Project of Chongqing Municipality (2020GDRC013) and Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0087) ."