Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris

作者全名："Shao, Xinyi; Chen, Yangmei; Zhang, Lingzhao; Zhang, Yujie; Ariyawati, Asoka; Chen, Tingqiao; Chen, Jiayi; Liu, Lin; Pu, Yihuan; Li, Yuxin; Chen, Jin"

作者地址："[Shao, Xinyi; Chen, Yangmei; Zhang, Lingzhao; Zhang, Yujie; Ariyawati, Asoka; Chen, Tingqiao; Chen, Jiayi; Liu, Lin; Pu, Yihuan; Li, Yuxin; Chen, Jin] Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Chen, J (通讯作者)，Chongqing Med Univ, Dept Dermatol, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：DERMATOLOGY AND THERAPY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000880514300001

JCR分区：Q2

影响因子：3.4

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Inflammation; Microbiota; Moderate-to-severe acne vulgaris; Skin; Supramolecular salicylic acid

摘要："Introduction Thirty-percent supramolecular salicylic acid (SSA), a modified salicylic acid preparation, is a safe and effective treatment for moderate-to-severe acne vulgaris (AV). However, its mechanism of action remains unclear. We aimed to analyze the role of 30% SSA peels on skin microbiota and inflammation in patients with moderate-to-severe AV. Methods A total of 28 patients were enrolled and received 30% SSA peels biweekly for 2 months. The Global Acne Grading System (GAGS) score, skin water content, transepidermal water loss (TEWL), pH, and sebum levels were assessed. Skin microbial samples and perilesional skin biopsies were obtained at the onset and 2 weeks after treatment completion. Samples were characterized using a high-throughput sequencing approach targeting a portion of the bacterial 16S ribosomal RNA gene. Results After treatment, patients showed a significant improvement in their GAGS score and skin barrier indicators (P < 0.05). The GAGS score was positively associated with both the sebum concentration (R = 0.3, P = 0.027) and pH (R = 0.39, P = 0.003). Increased expression of caveolin-1 and decreased expression of interleukin (IL)-1a, IL-6, IL-17, transforming growth factor beta, and toll-like receptor 2 were observed in the skin tissue after treatment. The richness and evenness of the cutaneous microbiome decreased after treatment and the Staphylococcus proportion decreased significantly (P < 0.05), whereas the Propionibacterium proportion tended to decrease (P = 0.066). Conclusions On the basis of analyses of the skin barrier and microbiota, we speculate that the 30% SSA peel may have a therapeutic effect in patients with moderate-to-severe AV by improving the skin microenvironment and modulating the skin microbiome, thus reducing local inflammation."

基金机构：National Natural Science Foundation of China [n82073462]

基金资助正文：This study was supported by the National Natural Science Foundation of China (n82073462). The journal's Rapid Service Fee was funded by the authors.