Prognostic and immunological role of FCER1G in pan-cancer

作者全名："Zhang, Xiaoxuan; Cai, Jing; Song, Fangzhou; Yang, Zhenzhou"

作者地址："[Zhang, Xiaoxuan; Yang, Zhenzhou] Chongqing Med Univ, Affiliated Hosp 2, Dept Canc Ctr, Chongqing 400010, Peoples R China; [Zhang, Xiaoxuan; Cai, Jing; Song, Fangzhou] Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China; [Zhang, Xiaoxuan; Cai, Jing; Song, Fangzhou] Chongqing Med Univ, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China; [Song, Fangzhou] Chongqing Med Univ, Dept Biochem & Mol Biol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China"

通信作者："Yang, ZZ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Canc Ctr, Chongqing 400010, Peoples R China.; Song, FZ (通讯作者)，Chongqing Med Univ, Dept Biochem & Mol Biol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China."

来源：PATHOLOGY RESEARCH AND PRACTICE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000880847300002

JCR分区：Q2

影响因子：2.8

年份：2022

卷号：240

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：FCER1G; Pan-cancer; Prognosis; Immune infiltration; Tumor microenvironment

摘要："The high-affinity IgE receptor gamma subunit gene (FCER1G) plays a pivotal role in allergic inflammatory signaling, which is closely associated with allergic reactions. Previous studies have shown that FCER1G is an innate immunity gene and is involved in the development of many diseases. However, the role of FCER1G in pan-cancer has not been fully studied. This study aimed to explore the prognostic value of FCER1G in pan-cancer and investigate the relationship between FCER1G expression and immune infiltration. We analyzed FCER1G mRNA expression in the Oncomine, TIMER, and GEPIA databases. We used GEPIA, PrognoScan, and Kaplan-Meier Plotter to analyze the prognostic value of FCER1G. We explored the correlations between FCER1G expression and immune infiltration in TIMER databases. Cytoscape was used to perform pathway enrichment and functional enrichment analyses. Spearman method was used to determine the statistical significance.FCER1G can act as a prognostic marker for pan-cancer, FCER1G expression can affect patients' prognosis and correlate with immune cells infiltration. In kidney renal clear cell carcinoma and thyroid carcinoma, FCER1G is closely associated with different immune cells infiltration states and tumor purity, and immune infiltration can interact with FCER1G-mediated activities both in tumor cells and immune cells. FCER1G can be used to predict the efficacy of immunological checkpoint therapy among these types of tumors patients. Our study also provides an important basis for the clinical use of FCER1G to assess the patient immune status and the selection of individualized immunotherapy options."

基金机构：Natural Science Foundation of Chongqing in China; National Natural Science Foundation of China; [cstc2021jcyj-bshX0073]; [81972851]

基金资助正文："This work was supported by the Natural Science Foundation of Chongqing in China under Grant number cstc2021jcyj-bshX0073 project to Xiaoxuan Zhang, and National Natural Science Foundation of China under Grant number 81972851 project to Zhenzhou Yang."