Polarization clustering of biological structures with Mueller matrix parameters

作者全名："Chen, Yongtai; Chu, Jinkui; Lin, Fanlu; Jiang, Bing; Liu, Yadong; Huang, Bo; Zhang, Ran; Xin, Benda; Ding, Xiaohan"

作者地址："[Chen, Yongtai; Chu, Jinkui; Zhang, Ran; Xin, Benda; Ding, Xiaohan] Dalian Univ Technol, Sch Mech Engn, Dalian 116024, Peoples R China; [Lin, Fanlu] Linyi Cent Hosp, Dept Urol, Linyi, Shandong, Peoples R China; [Jiang, Bing; Huang, Bo] Liaoning Canc Hosp & Inst, Dept Pathol, Shenyang 110042, Liaoning, Peoples R China; [Liu, Yadong] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing, Peoples R China"

通信作者："Chu, JK (通讯作者)，Dalian Univ Technol, Sch Mech Engn, Dalian 116024, Peoples R China.; Huang, B (通讯作者)，Liaoning Canc Hosp & Inst, Dept Pathol, Shenyang 110042, Liaoning, Peoples R China."

来源：JOURNAL OF BIOPHOTONICS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000881832800001

JCR分区：Q2

影响因子：2.8

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：classification of biological structures; Mueller matrix imaging; pathological diagnosis; polarization microscopy

摘要："Mueller matrix imaging polarimetry (MMIP) is a promising technique for the characterization of biological tissues, including the classification of microstructures in pathological diagnosis. To expand the parameter space of Mueller matrix parameters, we propose new vector parameters (VPs) according to the Mueller matrix polar decomposition method. We measure invasive bladder cancer (IBC) with extensive necrosis and high-grade ductal carcinoma in situ (DCIS) with MMIP, and the regions of cancer cells and fibrotic stroma are classified with the VPs. Then the proposed and existing VPs are mapped on the Poincare sphere with 3D visualization, and an indicator of spatial feature is defined based on the minimum enclosing sphere to evaluate the classification capability of the VPs. For both IBC and DCIS, the results show that the proposed VPs exhibit evident contrast between the regions of cancer cells and fibrotic stroma. This study broadens the fundamental Mueller matrix parameters and helps to improve the characterization ability of the MMIP technique."

基金机构："Fundamental Research Funds for the Central Universities [DUT20LAB303, DUT21GF308, DUT21ZD101]; NSFC and Science Fund for Creative Research Groups of NSFC [51621064, 51675076, 52175265]"

基金资助正文："the Fundamental Research Funds for the Central Universities, Grant/Award Numbers: DUT20LAB303, DUT21GF308, DUT21ZD101; the NSFC and Science Fund for Creative Research Groups of NSFC, Grant/Award Numbers: 51621064, 51675076, 52175265"