Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo

作者全名："Wang, Jinkui; Li, Mujie; Jin, Liming; Guo, Peng; Zhang, Zhaoxia; Zhanghuang, Chenghao; Tan, Xiaojun; Mi, Tao; Liu, Jiayan; Wu, Xin; Wei, Guanghui; He, Dawei"

作者地址："[Wang, Jinkui; Li, Mujie; Jin, Liming; Zhang, Zhaoxia; Zhanghuang, Chenghao; Tan, Xiaojun; Mi, Tao; Liu, Jiayan; Wu, Xin; Wei, Guanghui; He, Dawei] Chongqing Med Univ, Dept Urol, Childrens Hosp, 2 ZhongShan Rd, Chongqing 400013, Peoples R China; [Wang, Jinkui; Li, Mujie; Jin, Liming; Zhang, Zhaoxia; Zhanghuang, Chenghao; Tan, Xiaojun; Mi, Tao; Liu, Jiayan; Wu, Xin; Wei, Guanghui; He, Dawei] Chongqing Med Univ, Chongqing Key Lab Children Urogenital Dev & Tissu, Childrens Hosp, Chongqing, Peoples R China; [Wang, Jinkui; Li, Mujie; Jin, Liming; Zhang, Zhaoxia; Zhanghuang, Chenghao; Tan, Xiaojun; Mi, Tao; Liu, Jiayan; Wu, Xin; Wei, Guanghui; He, Dawei] Chongqing Med Univ, Chongqing Key Lab Pediat, Childrens Hosp, Chongqing, Peoples R China; [Wang, Jinkui; Li, Mujie; Jin, Liming; Zhang, Zhaoxia; Zhanghuang, Chenghao; Tan, Xiaojun; Mi, Tao; Liu, Jiayan; Wu, Xin; Wei, Guanghui; He, Dawei] Chongqing Med Univ, Key Lab Child Dev & Disorders, Childrens Hosp, Minist Educ, Chongqing, Peoples R China; [Wang, Jinkui; Li, Mujie; Jin, Liming; Zhang, Zhaoxia; Zhanghuang, Chenghao; Tan, Xiaojun; Mi, Tao; Liu, Jiayan; Wu, Xin; Wei, Guanghui; He, Dawei] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Chongqing, Peoples R China; [Wang, Jinkui; Li, Mujie; Jin, Liming; Zhang, Zhaoxia; Zhanghuang, Chenghao; Tan, Xiaojun; Mi, Tao; Liu, Jiayan; Wu, Xin; Wei, Guanghui; He, Dawei] Chongqing Med Univ, Childrens Hosp, China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China; [Guo, Peng] Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Zhejiang, Peoples R China"

通信作者："He, DW (通讯作者)，Chongqing Med Univ, Dept Urol, Childrens Hosp, 2 ZhongShan Rd, Chongqing 400013, Peoples R China."

来源：DRUG DELIVERY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000882134400001

JCR分区：Q1

影响因子：6

年份：2022

卷号：29

期号：1

开始页：3291

结束页：3303

文献类型：Article

关键词：Bone marrow mesenchymal stem cells; exosome mimetics; doxorubicin; osteosarcoma; drug delivery

摘要："Osteosarcoma is a bone tumor with a high incidence in children and adolescents. Chemotherapy for osteosarcoma is limited, and effective targeted drugs are urgently needed to treat osteosarcoma. Exosomes as a natural nano drug delivery platform have been widely studied and proven to have good drug delivery performance. However, the low production of exosomes hinders its development as a carrier. Exosome mimetics (EMs) as an alternative product of exosomes solve the problem of low production of exosomes and maintain the good performance of exosomes as carriers. In this study, bone marrow mesenchymal stem cells (BMSCs) were sequentially extruded to generate EMs to encapsulate doxorubicin (EM-Dox) to treat osteosarcoma. The results showed that we successfully prepared EMs of BMSC, and EM-Dox was prepared using an active-loading approach. Our engineered EM-Dox demonstrated significantly more potent tumor inhibition activity and fewer side effects than free doxorubicin. This novel biological nanomedicine system provides a promising opportunity to develop novel precision medicine for osteosarcoma."

基金机构：Special Key Project of Chongqing Technology Innovation and Application Development [Cstc2019jscx-tjsbX0003]

基金资助正文：This study was supported by Special Key Project of Chongqing Technology Innovation and Application Development (No. Cstc2019jscx-tjsbX0003).