Isovitexin restores sevoflurane-induced cognitive dysfunction by mediating autophagy through activation of the PGC-1 alpha/FNDC5 signaling pathway

作者全名："Guo, Yuanyuan; Chen, Qibin; Wu, Bin; Sun, Lin"

作者地址："[Guo, Yuanyuan; Chen, Qibin; Wu, Bin; Sun, Lin] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China"

通信作者："Guo, YY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China."

来源：ACTA NEUROBIOLOGIAE EXPERIMENTALIS

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000883011300013

JCR分区：Q4

影响因子：1.4

年份：2022

卷号：82

期号：3

开始页：373

结束页：379

文献类型：Article

关键词：postoperative cognitive dysfunction; isovitexin; sevoflurane; autophagy; PGC-1 alpha/FNDC5 pathway

摘要："Postoperative cognitive dysfunction is a severe neurological complication. How to improve the cognitive impairment caused by sevoflurane, a most common inhaled anesthetic, remains a question worthy of studying. Isovitexin (IVX) is a trihydroxyl flavonoid that is a naturally bioactive ingredient found in various medicinal plants and has antioxidant, anti-inflammatory and neuroprotective properties. The role of IVX in anesthetic-induced nerve injury is rarely reported and the mechanisms are unclear. In this study, we found that IVX improved the cognitive dysfunction induced by sevoflurane in rats. It inhibited sevoflurane-induced cell apoptosis. In addition, IVX increased sevoflurane-induced autophagy in rat brain. Mechanically, IVX activated the PGC-1 alpha/FNDC5 pathway in rat brain, and depletion of FNDC5 could inhibit the neuroprotective function of IVX. In conclusion, our results suggested that IVX restored sevoflurane-induced cognitive dysfunction by mediating autophagy through the activation of the PGC-1 alpha/FNDC5 pathway."

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