Isovitexin restores sevoflurane-induced cognitive dysfunction by mediating autophagy through activation of the PGC-1 alpha/FNDC5 signaling pathway

作者全名:"Guo, Yuanyuan; Chen, Qibin; Wu, Bin; Sun, Lin"

作者地址:"[Guo, Yuanyuan; Chen, Qibin; Wu, Bin; Sun, Lin] Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China"

通信作者:"Guo, YY (通讯作者),Chongqing Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Chongqing, Peoples R China."

来源:ACTA NEUROBIOLOGIAE EXPERIMENTALIS

ESI学科分类:NEUROSCIENCE & BEHAVIOR

WOS号:WOS:000883011300013

JCR分区:Q4

影响因子:1.4

年份:2022

卷号:82

期号:3

开始页:373

结束页:379

文献类型:Article

关键词:postoperative cognitive dysfunction; isovitexin; sevoflurane; autophagy; PGC-1 alpha/FNDC5 pathway

摘要:"Postoperative cognitive dysfunction is a severe neurological complication. How to improve the cognitive impairment caused by sevoflurane, a most common inhaled anesthetic, remains a question worthy of studying. Isovitexin (IVX) is a trihydroxyl flavonoid that is a naturally bioactive ingredient found in various medicinal plants and has antioxidant, anti-inflammatory and neuroprotective properties. The role of IVX in anesthetic-induced nerve injury is rarely reported and the mechanisms are unclear. In this study, we found that IVX improved the cognitive dysfunction induced by sevoflurane in rats. It inhibited sevoflurane-induced cell apoptosis. In addition, IVX increased sevoflurane-induced autophagy in rat brain. Mechanically, IVX activated the PGC-1 alpha/FNDC5 pathway in rat brain, and depletion of FNDC5 could inhibit the neuroprotective function of IVX. In conclusion, our results suggested that IVX restored sevoflurane-induced cognitive dysfunction by mediating autophagy through the activation of the PGC-1 alpha/FNDC5 pathway."

基金机构: 

基金资助正文: