A Biomimetic Smart Nanoplatform as ?Inflammation Scavenger? for Regenerative Therapy of Periodontal Tissue

作者全名："Chen, Poyu; Zhang, Chuangwei; He, Ping; Pan, Shengyuan; Zhong, Wenjie; Wang, Yue; Xiao, Qingyue; Wang, Xinyan; Yu, Wenliang; He, Zhangmin; Gao, Xiang; Song, Jinlin"

作者地址："[Chen, Poyu; Zhang, Chuangwei; Pan, Shengyuan; Zhong, Wenjie; Wang, Yue; Xiao, Qingyue; Wang, Xinyan; Yu, Wenliang; He, Zhangmin; Gao, Xiang; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing 401147, Peoples R China; [Chen, Poyu; Zhang, Chuangwei; Pan, Shengyuan; Zhong, Wenjie; Wang, Yue; Xiao, Qingyue; Wang, Xinyan; Yu, Wenliang; He, Zhangmin; Gao, Xiang; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China; [Chen, Poyu; Zhang, Chuangwei; Pan, Shengyuan; Zhong, Wenjie; Wang, Yue; Xiao, Qingyue; Wang, Xinyan; Yu, Wenliang; He, Zhangmin; Gao, Xiang; Song, Jinlin] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing 401147, Peoples R China; [He, Ping] Dazhou Cent Hosp, Dept Stomatol, Dazhou 635000, Sichuan, Peoples R China; [Gao, Xiang; Song, Jinlin] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China"

通信作者："Gao, X; Song, JL (通讯作者)，Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing 401147, Peoples R China."

来源：INTERNATIONAL JOURNAL OF NANOMEDICINE

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000884903100001

JCR分区：Q1

影响因子：8

年份：2022

卷号：17

期号：　

开始页：5165

结束页：5186

文献类型：Article

关键词：periodontal bone regeneration; pH-responsive; inflammatory modulation; antibacterial activity; biomimetic nanoplatform

摘要："Introduction: The functional reconstruction of periodontal tissue defects remains a clinical challenge due to excessive and prolonged host response to various endogenous and exogenous pro-inflammatory stimuli. Thus, a biomimetic nanoplatform with the capability of modulating inflammatory response in a microenvironment-responsive manner is attractive for regenerative therapy of periodontal tissue. Methods: Herein, a facile and green design of engineered bone graft materials was developed by integrating a biomimetic apatite nanocomposite with a smart-release coating, which could realize inflammatory modulation by ""on-demand"" delivery of the anti-inflammatory agent through a pH-sensing mechanism. Results: In vitro and in vivo experiments demonstrated that this biocompatible nanoplatform could facilitate the clearance of reactive oxygen species in human periodontal ligament stem cells under inflammatory conditions via inhibiting the production of endogenous proinflammatory mediators, in turn contributing to the enhanced healing efficacy of periodontal tissue. Moreover, this system exhibited effective antimicrobial activity against common pathogenic bacteria in the oral cavity, which is beneficial for the elimination of exogenous pro-inflammatory factors from bacterial infection during healing of periodontal tissue. Conclusion: The proposed strategy provides a versatile apatite nanocomposite as a promising ""inflammation scavenger"" and propels the development of intelligent bone graft materials for periodontal and orthopedic applications."

基金机构："Chongqing Postdoctoral Science Foundation; Postdoctoral Fund Project of the Chongqing Natural Science Foundation; Program for Youth Innovation in Future Medicine, Chongqing Medical University; [X11229]; [cstc2021jcyj-bshX0101]; [W0055]"

基金资助正文："Acknowledgments This work was supported in part by the Chongqing Postdoctoral Science Foundation (X11229) , the Postdoctoral Fund Project of the Chongqing Natural Science Foundation (cstc2021jcyj-bshX0101) , and Program for Youth Innovation in Future Medicine, Chongqing Medical University (W0055) ."