Prevalence of Heavy Menstrual Bleeding and Its Associated Cognitive Risks and Predictive Factors in Women With Severe Mental Disorders

作者全名："Shan, Jianmin; Tian, Hongjun; Zhou, Chunhua; Wang, Haibo; Ma, Xiaoyan; Li, Ranli; Yu, Haiping; Chen, Guangdong; Zhu, Jingjing; Cai, Ziyao; Lin, Chongguang; Cheng, Langlang; Xu, Yong; Liu, Sha; Zhang, Congpei; Luo, Qinghua; Zhang, Yunshu; Jin, Shili; Liu, Chuanxin; Zhang, Qiuyu; Lv, Luxian; Yang, Lei; Chen, Jiayue; Li, Qianchen; Liu, Wei; Yue, Weihua; Song, Xueqin; Zhuo, Chuanjun"

作者地址："[Shan, Jianmin; Yu, Haiping; Chen, Guangdong; Zhu, Jingjing; Cai, Ziyao; Lin, Chongguang; Cheng, Langlang; Zhuo, Chuanjun] Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China; [Shan, Jianmin; Tian, Hongjun; Zhuo, Chuanjun] Wenzhou Seventh Peoples Hosp, Dept Psychiat, Wenzhou, Peoples R China; [Zhou, Chunhua; Li, Qianchen] Hebei Med Univ, Dept Pharmacol, Hosp 1, Shijiazhuang, Hebei, Peoples R China; [Wang, Haibo] Peking Univ, Peking Univ Hosp 1, Clin Res Inst, Beijing, Peoples R China; [Ma, Xiaoyan; Li, Ranli] Tianjin Anding Hosp, MECT Ctr, Sleep Disorder Ctr, Tianjin, Peoples R China; [Xu, Yong; Liu, Sha] Shanxi Med Univ, Dept Psychiat, Hosp 1, Clin Med Coll 1, Taiyuan, Peoples R China; [Zhang, Congpei] Harbin First Psychiat Hosp, Inpatient Dept, Harbin, Peoples R China; [Luo, Qinghua] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhang, Yunshu] Hebei Mental Hlth Ctr, Inpatient Dept, Baoding, Peoples R China; [Jin, Shili] Shandong Daizhuang Hosp, Inpatient Dept, Jining, Peoples R China; [Liu, Chuanxin; Zhang, Qiuyu] Jining Med Univ, Inst Psychiat, Jinning, Peoples R China; [Lv, Luxian] Henan Psychiat Hosp, Dept Psychiat, Xinxiang, Henan, Peoples R China; [Yang, Lei] Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China; [Yang, Lei] Peking Univ Sixth Hosp, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China; [Chen, Jiayue; Yue, Weihua] Harbin Med Univ, Dept Psychiat, Hosp 1, Harbin, Peoples R China; [Liu, Wei; Song, Xueqin; Zhuo, Chuanjun] Zhengzhou Univ, Dept Psychiat, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Zhuo, Chuanjun] Tianjin Med Univ, Tianjin Anding Hosp, Lab Psychiat Neuroimaging Genet & Cor Morbid, Tianjin Mental Hlth Ctr, Tianjin, Peoples R China"

通信作者："Zhuo, CJ (通讯作者)，Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China.; Zhuo, CJ (通讯作者)，Wenzhou Seventh Peoples Hosp, Dept Psychiat, Wenzhou, Peoples R China.; Yue, WH (通讯作者)，Harbin Med Univ, Dept Psychiat, Hosp 1, Harbin, Peoples R China.; Liu, W; Song, XQ; Zhuo, CJ (通讯作者)，Zhengzhou Univ, Dept Psychiat, Affiliated Hosp 1, Zhengzhou, Peoples R China.; Zhuo, CJ (通讯作者)，Tianjin Med Univ, Tianjin Anding Hosp, Lab Psychiat Neuroimaging Genet & Cor Morbid, Tianjin Mental Hlth Ctr, Tianjin, Peoples R China."

来源：FRONTIERS IN PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000885770200001

JCR分区：Q1

影响因子：5.6

年份：2022

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：bipolar disorder; major depressive disorder; schizophrenia; heavy menstrual bleeding; visual learning; lithium

摘要："There has been limited studies examining treatment-induced heavy menstrual bleeding (HMB) in women with severe mental illnesses. The aim of this study was to examine HMB prevalence and HMB-associated factors in young women (18-34 years old) diagnosed with bipolar disorder (BP), major depressive disorder (MDD), or schizophrenia (SCZ) who have full insight and normal intelligence. Eighteen-month menstruation histories were recorded with pictorial blood loss assessment chart assessments of HMB. Multivariate analyses were conducted to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Drug effects on cognition were assessed with the MATRICS Consensus Cognitive Battery (MCCB). HMB prevalence were: BP, 25.85%; MDD, 18.78%; and SCH, 13.7%. High glycosylated hemoglobin (HbA1c) level was a strong risk factor for HMB [BP OR, 19.39 (16.60-23.01); MDD OR, 2.69 (4.59-13.78); and SCZ OR, 9.59 (6.14-12.43)]. Additional risk factors included fasting blood sugar, 2-h postprandial blood glucose, and use of the medication valproate [BP: OR, 16.00 (95%CI 12.74-20.22); MDD: OR, 13.88 (95%CI 11.24-17.03); and SCZ OR, 11.35 (95%CI 8.84-19.20)]. Antipsychotic, antidepressant, and electroconvulsive therapy use were minor risk factors. Pharmacotherapy-induced visual learning impairment was associated with HMB [BP: OR, 9.01 (95%CI 3.15-13.44); MDD: OR, 5.99 (95%CI 3.11-9.00); and SCZ: OR, 7.09 (95%CI 2.99-9.20)]. Lithium emerged as a protective factor against HMB [BP: OR, 0.22 (95%CI 0.14-0.40); MDD: OR, 0.30 (95%CI 0.20-0.62); and SCZ: OR, 0.65 (95%CI 0.33-0.90)]. In SCZ patients, hyperlipidemia and high total cholesterol were HMB-associated factors (ORs, 1.87-2.22). Psychiatrist awareness of HMB risk is concerningly low (12/257, 2.28%). In conclusion, prescription of VPA should be cautioned for women with mental illness, especially BP, and lithium may be protective against HMB."

基金机构："National Natural Science Foundation of China [81871052, 82171503]; Key Projects of the Natural Science Foundation of Tianjin, China [17JCZDJC35700]; Tianjin Health Bureau Foundation [2014KR02]; Tianjin Science and Technology Bureau [15JCYBJC50800]"

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (81871052, 82171503 to CZ); the Key Projects of the Natural Science Foundation of Tianjin, China (17JCZDJC35700 to CZ); the Tianjin Health Bureau Foundation (2014KR02 to CJZ; and the Tianjin Science and Technology Bureau (15JCYBJC50800 to HT)."