All-in-one Cu-mediated Ag-assembled nanocomposites for photothermal-assisted photo/chemical dynamic therapy with hypoxia relief and enhanced reactive oxygen species

作者全名："Zhou, Ping; Zhang, Xianming; Yu, Qinghua; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao"

作者地址："[Zhou, Ping; Zhang, Xianming; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Med Univ, Coll Pharm, Res Ctr Pharmaceut Preparat & Nanomed, Chongqing 400016, Peoples R China; [Zhou, Ping; Zhang, Xianming; Yang, Shiyu; Xia, Jiashan; Deng, Tao; Yu, Chao] Chongqing Key Lab Pharmaceut Metab Res, Coll Pharm, Chongqing 400016, Peoples R China; [Yu, Chao] Chongqing Pharmacodynam Evaluat Engn Technol Res C, Coll Pharm, Chongqing 400016, Peoples R China; [Yu, Qinghua] Chongqing Univ, Canc Hosp, Dept Pharm, Chongqing 400000, Peoples R China"

通信作者："Deng, T; Yu, C (通讯作者)，Chongqing Med Univ, Coll Pharm, Res Ctr Pharmaceut Preparat & Nanomed, Chongqing 400016, Peoples R China.; Deng, T; Yu, C (通讯作者)，Chongqing Key Lab Pharmaceut Metab Res, Coll Pharm, Chongqing 400016, Peoples R China.; Yu, C (通讯作者)，Chongqing Pharmacodynam Evaluat Engn Technol Res C, Coll Pharm, Chongqing 400016, Peoples R China."

来源：NEW JOURNAL OF CHEMISTRY

ESI学科分类：CHEMISTRY

WOS号：WOS:000886403700001

JCR分区：Q2

影响因子：3.3

年份：2022

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期号：　

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文献类型：Article; Early Access

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摘要："Silver nanoparticles (AgNPs) have a wide adjustable absorption range. However, it is highly difficult to synthesize AgNPs with NIR absorption and act as an agent for photodynamic therapy (PDT) and photothermal therapy (PTT). Herein, we have fabricated an integrated agent (Ag@Cu) with broad NIR absorption, which alleviated hypoxia and enhanced reactive oxygen species (ROS), resulting in the improvement of PDT efficacy. The obtained Ag@Cu exhibited relatively mild PTT to alleviate hypoxia by accelerating blood flow in the tumor microenvironment and making more oxygenated hemoglobin reach the tumor microenvironment to provide oxygen, which enhanced the efficiency of PDT. The metal ions-mediated inorganic nanoparticle assembly approach of introducing Cu2+ achieved efficient chemodynamic therapy (CDT), amplifying the intracellular oxidative stress to further enhance the effects of PDT. Significantly, adenosine triphosphate (ATP) and excess glutathione (GSH) in tumor cells can also be depleted by copper ions, enhancing the efficacy of ROS-mediated therapy. Therefore, fabricating functional nanomaterials by highly efficient self-assembly strategies that introduce functional metal ions is a favorable method for multimodal tumor treatment."

基金机构：Future Medical Youth Innovation Team Support Program of Chongqing Medical University; Chongqing Key Laboratory for Pharmaceutical Metabolism Research of Chongqing Medical University; [W0090]

基金资助正文：This work was financially supported by Future Medical Youth Innovation Team Support Program of Chongqing Medical University (W0090). We sincerely thank Research Center of Pharmaceutical Preparations and Nanomedicine and Chongqing Key Laboratory for Pharmaceutical Metabolism Research of Chongqing Medical University for the support of the work.